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Indobufen

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Chemical compound

Pharmaceutical compound

Indobufen
Clinical data


AHFS/Drugs.com	International Drug Names
ATC code	B01AC10 (WHO)
Identifiers
IUPAC name 2-(4-(1-Oxoisoindolin-2-yl)phenyl)butanoic acid
CAS Number	63610-08-2^Y
PubChemCID	107641
ChemSpider	96823^N
UNII	6T9949G4LZ
KEGG	D07141^Y
ChEMBL	ChEMBL1765292^N
CompTox Dashboard(EPA)	DTXSID7057789
ECHA InfoCard	100.058.496
Chemical and physical data
Formula	C₁₈H₁₇NO₃
Molar mass	295.338 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(O)C(c1ccc(cc1)N3C(=O)c2ccccc2C3)CC
InChI InChI=1S/C18H17NO3/c1-2-15(18(21)22)12-7-9-14(10-8-12)19-11-13-5-3-4-6-16(13)17(19)20/h3-10,15H,2,11H2,1H3,(H,21,22)^N Key:AYDXAULLCROVIT-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Indobufen is aplatelet aggregation inhibitor.^[1] It acts as a reversiblecyclooxygenase inhibitor.^[2]

^The Merck Index (12th ed.). p. 4991.
^Eligini S, Violi F, Banfi C, Barbieri SS, Brambilla M, Saliola M, et al. (January 2006)."Indobufen inhibits tissue factor in human monocytes through a thromboxane-mediated mechanism".Cardiovascular Research.69 (1):218–26.doi:10.1016/j.cardiores.2005.07.013.PMID 16154551.

Glycoprotein IIb/IIIa inhibitors	Abciximab Eptifibatide Orbofiban Roxifiban Sibrafiban^§ Tirofiban
ADP receptor/P2Y₁₂ inhibitors	Thienopyridines Clopidogrel Prasugrel Ticlopidine Nucleotide/nucleoside analogs Cangrelor Elinogrel Ticagrelor
Prostaglandin analogue (PGI2)	Beraprost Iloprost Prostacyclin Treprostinil
COX inhibitors	Acetylsalicylic acid/Aspirin^# Aloxiprin Carbasalate calcium Indobufen Triflusal
Thromboxane inhibitors	Thromboxane synthase inhibitors Dipyridamole (+ aspirin) Picotamide Terbogrel Receptor antagonists Terbogrel Terutroban^§
Phosphodiesterase inhibitors	Cilostazol Dipyridamole Triflusal
Other	Cloricromen Ditazole Vorapaxar

Factor Xa inhibitors
(with some II inhibition)

Heparin group/ glycosaminoglycans/ (bindantithrombin)	Low-molecular-weight heparin Bemiparin Certoparin Dalteparin Enoxaparin Nadroparin Parnaparin Reviparin Tinzaparin Oligosaccharides Fondaparinux Idraparinux^§ Heparinoids Danaparoid Dermatan sulfate Sulodexide
Direct Xa inhibitors ("xabans")	Apixaban Betrixaban Darexaban^§ Edoxaban Otamixaban^§ Rivaroxaban

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