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Impentamine

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Impentamine
Names

IUPAC name 5-(1H-imidazol-5-yl)pentan-1-amine
Identifiers
CAS Number	34973-91-6^Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL417096
ChemSpider	7969635^N
IUPHAR/BPS	1252
MeSH	Impentamine
PubChem CID	9793868
UNII	88JSL4TQ76^Y
CompTox Dashboard(EPA)	DTXSID70430734
InChI InChI=1S/C8H15N3/c9-5-3-1-2-4-8-6-10-7-11-8/h6-7H,1-5,9H2,(H,10,11)^N Key: MZCJWLAXZRFUPI-UHFFFAOYSA-N^N InChI=1/C8H15N3/c9-5-3-1-2-4-8-6-10-7-11-8/h6-7H,1-5,9H2,(H,10,11) Key: MZCJWLAXZRFUPI-UHFFFAOYAF
SMILES C1=C(NC=N1)CCCCCN
Properties
Chemical formula	C₈H₁₅N₃
Molar mass	153.2248 g/mol
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references

Chemical compound

Impentamine is ahistamine antagonist selective for theH₃ subtype.^[1]^[2]

^Vollinga, RC; Menge, WM; Leurs, R; Timmerman, H (1995). "Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole".Journal of Medicinal Chemistry.38 (2):266–71.doi:10.1021/jm00002a008.PMID 7830269.
^Van Der Goot, H; Timmerman, H (2000). "Selective ligands as tools to study histamine receptors".European Journal of Medicinal Chemistry.35 (1):5–20.doi:10.1016/S0223-5234(00)00101-X.PMID 10733599.

Agonists

Antagonists

Agonists	Amthamine Betazole Dimaprit Histamine HTMT Impromidine L-Histidine UR-AK49
Antagonists	Bisfentidine Burimamide Cimetidine Dalcotidine Donetidine Ebrotidine Etintidine Famotidine Isolamtidine Lafutidine Lamtidine Lavoltidine (loxtidine) Lupitidine Metiamide Mifentidine Niperotidine Nizatidine Osutidine Oxmetidine Pibutidine Quisultazine (quisultidine) Ramixotidine Ranitidine Roxatidine Sufotidine Tiotidine Tuvatidine Venritidine Xaltidine Zolantidine

Agonists	α-Methylhistamine BP 2.94 Cipralisant (GT-2331) GT-2203 (VUF-5296) Histamine Imetit Immepip Immethridine (BP-1-5375) L-Histidine Methimepip Proxyfan SCH-50971 VUF-5297
Antagonists	A-349821 A-423579 ABT-239 ABT-652 AZD5213 Bavisant Betahistine Burimamide Ciproxifan Clobenpropit Conessine Enerisant GSK-189254 Impentamine Iodophenpropit Irdabisant JNJ-5207852 NNC 38-1049 PF-03654746 Pitolisant SCH-79687 Thioperamide VUF-5681

Agonists	4-Methylhistamine α-Methylhistamine Histamine L-Histidine OUP-16 VUF-8430
Antagonists	JNJ-7777120 Mianserin Seliforant Thioperamide Toreforant VUF-6002

See also: Receptor/signaling modulators; Monoamine metabolism modulators; Monoamine reuptake inhibitors

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