Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

Ifoxetine

From Wikipedia, the free encyclopedia
Chemical compound
Not to be confused withFluoxetine.
Pharmaceutical compound
Ifoxetine
Clinical data
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • (3R,4S)-4-(2,3-dimethylphenoxy)piperidin-3-ol
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC13H19NO2
Molar mass221.300 g·mol−1
3D model (JSmol)
  • O(c1cccc(c1C)C)[C@H]2CCNC[C@H]2O

Ifoxetine (CGP-15,210-G) is aselective serotonin reuptake inhibitor (SSRI) which was investigated as anantidepressant in the 1980s but was never marketed.[1][2][3] Ifoxetineselectively blocks thereuptake ofserotonin in thebrain supposedly without affecting it in theperiphery.[3] Supporting this claim, ifoxetine was found to be efficacious inclinical trials and was very well tolerated, producing almost nophysicalside effects or other complaints of significant concern.[3]

References

[edit]
  1. ^Burrows GD, McIntyre IM, Judd FK, Norman TR (August 1988). "Clinical effects of serotonin reuptake inhibitors in the treatment of depressive illness".The Journal of Clinical Psychiatry. 49 Suppl:18–22.PMID 3045107.
  2. ^Waldmeier PC, Maître L, Baumann PA, et al. (October 1986). "Ifoxetine, a compound with atypical effects on serotonin uptake".European Journal of Pharmacology.130 (1–2):1–10.doi:10.1016/0014-2999(86)90177-9.PMID 2877890.
  3. ^abcDelini-Stula A, Fischbach R, Gauthier JM, et al. (July 1987). "First clinical experience with ifoxetine, a new 5-HT reuptake blocker with particular emphasis on the side-effect profile of the 5-HT-uptake inhibiting drugs".International Clinical Psychopharmacology.2 (3):201–15.doi:10.1097/00004850-198707000-00003.PMID 3320185.
SSRIsTooltip Selective serotonin reuptake inhibitors
SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors
NRIsTooltip Norepinephrine reuptake inhibitors
NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants
SARIsTooltip Serotonin antagonist and reuptake inhibitors
SMSTooltip Serotonin modulator and stimulators
Others
TCAsTooltip Tricyclic antidepressants
TeCAsTooltip Tetracyclic antidepressants
Others
Non-selective
MAOATooltip Monoamine oxidase A-selective
MAOBTooltip Monoamine oxidase B-selective
Miscellaneous
DATTooltip Dopamine transporter
(DRIsTooltip Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter
(NRIsTooltip Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter
(SRIsTooltip Serotonin reuptake inhibitors)
VMATsTooltip Vesicular monoamine transporters
Others


Stub icon

Thisdrug article relating to thenervous system is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Ifoxetine&oldid=1268851034"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2025 Movatter.jp