IVX-411 is a COVID-19 candidatenanoparticle vaccine under development byIcosavax currently undergoing a Phase I/II clinical trial in Australia.^[1] It was originally developed at theInstitute of Protein Design (IPD) and the University of Washington School of Medicine, both based at theUniversity of Washington.^[2][3][4]

In 2022 results were released that the RDB antigen component of the vaccine was unstable, which resulted in reduced potency.^[5]

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