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ITGB3BP

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

ITGB3BP

Identifiers

Aliases

ITGB3BP, CENP-R, CENPR, HSU37139, NRIF3, TAP20, integrin subunit beta 3 binding protein

External IDs

OMIM:605494;MGI:1914983;HomoloGene:8617;GeneCards:ITGB3BP;OMA:ITGB3BP - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p31.3	Start	63,440,770bp^[1]
Band	1p31.3	End	63,593,721bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 C6	Start	99,653,639bp^[2]
Band	4\|4 C6	End	99,787,010bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

Achilles tendon

secondary oocyte

testicle

right uterine tube

ventricular zone

sperm

ganglionic eminence

gonad

right testis

Top expressed in

testicle

spermatocyte

ventricular zone

spermatid

quadriceps femoris muscle

epiblast

embryo

proximal tubule

right kidney

neural tube

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	signal transducer activity protein C-terminus binding protein binding
Cellular component	cytoplasm cytosol membrane nucleoplasm chromosome chromosome, centromeric region nucleus kinetochore
Biological process	regulation of transcription, DNA-templated CENP-A containing chromatin assembly transcription, DNA-templated cell division cell adhesion positive regulation of apoptotic process cell cycle signal transduction apoptotic process
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


23421


67733

Ensembl


ENSG00000142856


ENSMUSG00000028549

UniProt


Q13352


Q9CQ82

RefSeq (mRNA)


NM_001206739 NM_014288 NM_001347145 NM_001347147 NM_001347148


NM_026348 NM_001362974 NM_001362975 NM_001362976

RefSeq (protein)


NP_001193668 NP_001334074 NP_001334076 NP_001334077 NP_055103


NP_080624 NP_001349903 NP_001349904 NP_001349905

Location (UCSC)

Chr 1: 63.44 – 63.59 Mb

Chr 4: 99.65 – 99.79 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Centromere protein R is aprotein that in humans is encoded by theITGB3BPgene.^[5]^[6]^[7]

Interactions

[edit]

ITGB3BP has been shown tointeract with:

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000142856 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000028549 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^bShattil SJ, O'Toole T, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH (December 1995)."Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit".J Cell Biol.131 (3):807–16.doi:10.1083/jcb.131.3.807.PMC 2120613.PMID 7593198.
^^a ^b ^cLi D, Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels HH (February 2000)."NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors".Mol Cell Biol.19 (10):7191–202.doi:10.1128/mcb.19.10.7191.PMC 84712.PMID 10490654.
^"Entrez Gene: ITGB3BP integrin beta 3 binding protein (beta3-endonexin)".
^Fujimoto TT, Katsutani S, Shimomura T, Fujimura K (January 2002). "Novel alternatively spliced form of beta(3)-endonexin".Thromb. Res.105 (1):63–70.doi:10.1016/s0049-3848(01)00405-4.PMID 11864709.
^Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Yamada M, Hatakeyama M (January 2000). "beta3-endonexin as a novel inhibitor of cyclin A-associated kinase".Biochem. Biophys. Res. Commun.267 (3):947–52.doi:10.1006/bbrc.1999.2007.PMID 10673397.
^Besta F, Massberg S, Brand K, Müller E, Page S, Grüner S, Lorenz M, Sadoul K, Kolanus W, Lengyel E, Gawaz M (October 2002)."Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor".J. Cell Sci.115 (Pt 20):3879–88.doi:10.1242/jcs.00081.PMID 12244126.
^^a ^bLi D, Wang F, Samuels HH (December 2001)."Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation".Mol. Cell. Biol.21 (24):8371–84.doi:10.1128/MCB.21.24.8371-8384.2001.PMC 100002.PMID 11713274.

Kashiwagi H, Schwartz MA, Eigenthaler M, Davis KA, Ginsberg MH, Shattil SJ (1997)."Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail".J. Cell Biol.137 (6):1433–43.doi:10.1083/jcb.137.6.1433.PMC 2132534.PMID 9182673.
Tang S, Gao Y, Ware JA (1999)."Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein".J. Cell Biol.147 (5):1073–84.doi:10.1083/jcb.147.5.1073.PMC 2169340.PMID 10579726.
Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Yamada M, Hatakeyama M (2000). "beta3-endonexin as a novel inhibitor of cyclin A-associated kinase".Biochem. Biophys. Res. Commun.267 (3):947–52.doi:10.1006/bbrc.1999.2007.PMID 10673397.
Li D, Wang F, Samuels HH (2001)."Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation".Mol. Cell. Biol.21 (24):8371–84.doi:10.1128/MCB.21.24.8371-8384.2001.PMC 100002.PMID 11713274.
Fujimoto TT, Katsutani S, Shimomura T, Fujimura K (2002). "Novel alternatively spliced form of beta(3)-endonexin".Thromb. Res.105 (1):63–70.doi:10.1016/S0049-3848(01)00405-4.PMID 11864709.
Besta F, Massberg S, Brand K, Müller E, Page S, Grüner S, Lorenz M, Sadoul K, Kolanus W, Lengyel E, Gawaz M (2003)."Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor".J. Cell Sci.115 (Pt 20):3879–88.doi:10.1242/jcs.00081.PMID 12244126.
Li D, Das S, Yamada T, Samuels HH (2004)."The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells".Mol. Cell. Biol.24 (9):3838–48.doi:10.1128/MCB.24.9.3838-3848.2004.PMC 387764.PMID 15082778.
Talukder AH, Gururaj A, Mishra SK, Vadlamudi RK, Kumar R (2004)."Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator".Mol. Cell. Biol.24 (15):6581–91.doi:10.1128/MCB.24.15.6581-6591.2004.PMC 444867.PMID 15254226.
Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (2006). "The human CENP-A centromeric nucleosome-associated complex".Nat. Cell Biol.8 (5):458–69.doi:10.1038/ncb1397.PMID 16622419.S2CID 205286556.
Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres".Nat. Cell Biol.8 (5):446–57.doi:10.1038/ncb1396.PMID 16622420.S2CID 26974412.

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