Protein-coding gene in the species Homo sapiens
Interferon regulatory factor 2 is aprotein that in humans is encoded by theIRF2 gene .[ 5]
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits theIRF1 -mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator ofhistone H4 .[ 6]
IRF2 has been shown tointeract withBRD7 ,[ 7] EP300 [ 8] PCAF .[ 8] [ 9]
^a b c GRCh38: Ensembl release 89: ENSG00000168310 –Ensembl , May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000031627 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T (September 1989). "Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes".Cell .58 (4):729– 39.doi :10.1016/0092-8674(89)90107-4 .PMID 2475256 .S2CID 2033941 . ^ "Entrez Gene: IRF2 interferon regulatory factor 2" .^ Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2".J. Cell. Physiol .185 (2):269– 79.doi :10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L .PMID 11025449 .S2CID 22932901 . ^a b Masumi A, Ozato K (June 2001)."Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment" .J. Biol. Chem .276 (24):20973– 80.doi :10.1074/jbc.M101707200 PMID 11304541 . ^ Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K (March 1999)."The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness" .Mol. Cell. Biol .19 (3):1810– 20.doi :10.1128/MCB.19.3.1810 .PMC 83974 PMID 10022868 . Harada H, Taniguchi T, Tanaka N (1999). "The role of interferon regulatory factors in the interferon system and cell growth control".Biochimie .80 (8– 9):641– 50.doi :10.1016/S0300-9084(99)80017-0 .PMID 9865486 . 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Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995)."Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF) .Nature .377 (6547 Suppl):3– 174.PMID 7566098 . Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ (1995)."Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors" .J. Biol. Chem .270 (22):13063– 9.doi :10.1074/jbc.270.22.13063 PMID 7768900 . Cha Y, Deisseroth AB (1994)."Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region" .J. Biol. Chem .269 (7):5279– 87.doi :10.1016/S0021-9258(17)37685-8 PMID 8106512 . Harada H, Kitagawa M, Tanaka N, Yamamoto H, Harada K, Ishihara M, Taniguchi T (1993). "Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2".Science .259 (5097):971– 4.Bibcode :1993Sci...259..971H .doi :10.1126/science.8438157 .PMID 8438157 .S2CID 41036818 . Drew PD, Franzoso G, Carlson LM, Biddison WE, Siebenlist U, Ozato K (1996)."Interferon regulatory factor-2 physically interacts with NF-kappa B in vitro and inhibits NF-kappa B induction of major histocompatibility class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells" .J. Neuroimmunol .63 (2):157– 62.doi :10.1016/0165-5728(95)00140-9 .PMID 8550813 .S2CID 53166594 . Birnbaum MJ, van Zundert B, Vaughan PS, Whitmarsh AJ, van Wijnen AJ, Davis RJ, Stein GS, Stein JL (1997). "Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo".J. Cell. Biochem .66 (2):175– 83.doi :10.1002/(SICI)1097-4644(19970801)66:2<175::AID-JCB5>3.0.CO;2-N .PMID 9213219 .S2CID 34485265 . Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K (1999)."The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness" .Mol. Cell. Biol .19 (3):1810– 20.doi :10.1128/MCB.19.3.1810 .PMC 83974 PMID 10022868 . Li W, Nagineni CN, Hooks JJ, Chepelinsky AB, Egwuagu CE (1999). "Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors".Invest. Ophthalmol. Vis. Sci .40 (5):976– 82.PMID 10102295 . Whitney LW, Becker KG, Tresser NJ, Caballero-Ramos CI, Munson PJ, Prabhu VV, Trent JM, McFarland HF, Biddison WE (1999). "Analysis of gene expression in multiple sclerosis lesions using cDNA microarrays".Ann. Neurol .46 (3):425– 8.doi :10.1002/1531-8249(199909)46:3<425::AID-ANA22>3.0.CO;2-O .PMID 10482277 .S2CID 85574347 . Mild GC, Schmahl GE, Shayan P, Niemeyer CM (2000). "Expression of interferon regulatory factor 1 and 2 in hematopoietic cells of children with juvenile myelomonocytic leukemia".Leuk. Lymphoma .35 (5– 6):507– 11.doi :10.1080/10428199909169615 .PMID 10609788 . Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ (2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2".J. Cell. Physiol .185 (2):269– 79.doi :10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L .PMID 11025449 .S2CID 22932901 . Larrea E, Alberdi A, Castelruiz Y, Boya P, Civeira MP, Prieto J (2001). "Expression of interferon-alpha subtypes in peripheral mononuclear cells from patients with chronic hepatitis C: a role for interferon-alpha5".J. Viral Hepat .8 (2):103– 10.doi :10.1046/j.1365-2893.2001.00273.x .PMID 11264730 .S2CID 55595193 . Masumi A, Ozato K (2001)."Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment" .J. Biol. Chem .276 (24):20973– 80.doi :10.1074/jbc.M101707200 PMID 11304541 . This article incorporates text from theUnited States National Library of Medicine , which is in thepublic domain .
PDB gallery
1irf : INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
1irg : INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, 20 STRUCTURES
2irf : CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4)β-Scaffold factors with minor groove contacts
(0) Other transcription factors
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