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IRAK2

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From Wikipedia, the free encyclopedia

Protein-coding gene in humans

IRAK2

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
3MOP

Identifiers

Aliases

IRAK2, IRAK-2, interleukin 1 receptor associated kinase 2

External IDs

OMIM:603304;MGI:2429603;HomoloGene:1207;GeneCards:IRAK2;OMA:IRAK2 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p25.3	Start	10,164,919bp^[1]
Band	3p25.3	End	10,243,745bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6 E3\|6 52.82 cM	Start	113,615,428bp^[2]
Band	6 E3\|6 52.82 cM	End	113,671,987bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cartilage tissue

pancreatic epithelial cell

secondary oocyte

pancreatic ductal cell

palpebral conjunctiva

gastrocnemius muscle

tibialis anterior muscle

amniotic fluid

endothelial cell

islet of Langerhans

Top expressed in

granulocyte

jejunum

urinary bladder

white adipose tissue

spleen

left lung

colon

proximal tubule

duodenum

ileum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding protein kinase activity protein homodimerization activity protein serine/threonine kinase activity protein binding protein heterodimerization activity ATP binding
Cellular component	cytoplasm cytosol plasma membrane endosome membrane nucleus
Biological process	response to interleukin-1 negative regulation of DNA-binding transcription factor activity toll-like receptor signaling pathway protein phosphorylation JNK cascade positive regulation of NF-kappaB transcription factor activity toll-like receptor 9 signaling pathway negative regulation of NF-kappaB transcription factor activity nucleotide-binding oligomerization domain containing signaling pathway lipopolysaccharide-mediated signaling pathway signal transduction regulation of cytokine-mediated signaling pathway I-kappaB kinase/NF-kappaB signaling inflammatory response MyD88-dependent toll-like receptor signaling pathway intracellular signal transduction interleukin-1-mediated signaling pathway cytokine-mediated signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


3656


108960

Ensembl


ENSG00000134070


ENSMUSG00000060477

UniProt


O43187


Q8CFA1

RefSeq (mRNA)


NM_001570


NM_001113553 NM_172161

RefSeq (protein)


NP_001561


NP_001107025 NP_751893

Location (UCSC)

Chr 3: 10.16 – 10.24 Mb

Chr 6: 113.62 – 113.67 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Interleukin-1 receptor-associated kinase-like 2 is anenzyme that in humans is encoded by theIRAK2gene.^[5]^[6]

Function

[edit]

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.^[6]

Interactions

[edit]

IRAK2 has been shown tointeract withTRAF6^[5]^[7] andMyd88.^[5]^[7]^[8]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000134070 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000060477 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^b ^cMuzio M, Ni J, Feng P, Dixit VM (Nov 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling".Science.278 (5343):1612–5.Bibcode:1997Sci...278.1612M.doi:10.1126/science.278.5343.1612.PMID 9374458.
^^a ^b"Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2".
^^a ^bWesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999)."IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family".The Journal of Biological Chemistry.274 (27):19403–10.doi:10.1074/jbc.274.27.19403.PMID 10383454.
^Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction".Nature.413 (6851):78–83.Bibcode:2001Natur.413...78F.doi:10.1038/35092578.PMID 11544529.S2CID 4333764.

Auron PE (1999). "The interleukin 1 receptor: ligand interactions and signal transduction".Cytokine & Growth Factor Reviews.9 (3–4):221–37.doi:10.1016/S1359-6101(98)00018-5.PMID 9918122.
Maschera B, Ray K, Burns K, Volpe F (Apr 1999)."Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB".The Biochemical Journal. 339 ( Pt 2) (2):227–31.doi:10.1042/0264-6021:3390227.PMC 1220149.PMID 10191251.
Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999)."IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family".The Journal of Biological Chemistry.274 (27):19403–10.doi:10.1074/jbc.274.27.19403.PMID 10383454.
Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction".Nature.413 (6851):78–83.Bibcode:2001Natur.413...78F.doi:10.1038/35092578.PMID 11544529.S2CID 4333764.
McDermott EP, O'Neill LA (Mar 2002)."Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1".The Journal of Biological Chemistry.277 (10):7808–15.doi:10.1074/jbc.M108133200.hdl:2262/33695.PMID 11744690.
Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM (Feb 2003)."Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function".The Journal of Biological Chemistry.278 (9):7607–16.doi:10.1074/jbc.M210455200.PMID 12493773.
Bin LH, Xu LG, Shu HB (Jul 2003)."TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling".The Journal of Biological Chemistry.278 (27):24526–32.doi:10.1074/jbc.M303451200.PMID 12721283.
Kuzmin I, Geil L, Gibson L, Cavinato T, Loukinov D, Lobanenkov V, Lerman MI (Feb 2005). "Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter".Journal of Molecular Biology.346 (2):411–22.doi:10.1016/j.jmb.2004.11.066.PMID 15670593.
Keating SE, Maloney GM, Moran EM, Bowie AG (Nov 2007)."IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination".The Journal of Biological Chemistry.282 (46):33435–43.doi:10.1074/jbc.M705266200.PMID 17878161.

Kinases:Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1
Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3 PDK4
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4
Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase Aurora C kinase
Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-
IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP
cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY
cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1
Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3
Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase
Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2
G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6
Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK1A CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1
Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4
Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2
Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19
Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4
Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1
Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14
MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14
Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-
Tropomyosin kinase (EC 2.7.11.28)	-
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-
Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

Cytokine receptor modulators

Chemokine

Seehere instead.

CSF

Erythropoietin	Agonists:ARA-290 Asialo erythropoietin Carbamylated erythropoietin CNTO-530 Darbepoetin alfa Epoetin alfa Epoetin beta Epoetin delta Epoetin epsilon Epoetin gamma Epoetin kappa Epoetin omega Epoetin theta Epoetin zeta Erythropoietin (EPO) Erythropoietin-Fc Methoxy polyethylene glycol-epoetin beta (CERA/Mircera) Peginesatide Pegol sihematide (EPO-018B)
G-CSF (CSF3)	Agonists:Filgrastim Granulocyte colony-stimulating factor Lenograstim Leridistim Lipegfilgrastim Nartograstim Pegfilgrastim Pegnartograstim
GM-CSF (CSF2)	Agonists:Ecogramostim Granulocyte macrophage colony-stimulating factor Milodistim Molgramostim Regramostim Sargramostim Antibodies:Mavrilimumab Namilumab Otilimab
M-CSF (CSF1)	Agonists:Cilmostim Interleukin-34 Lanimostim Macrophage colony-stimulating factor Mirimostim Kinase inhibitors:Agerafenib
SCF (c-Kit)	Seehere instead.
Thrombopoietin	Agonists:Eltrombopag Pegacaristim Promegapoietin Romiplostim Thrombopoietin (THPO, MGDF)

Interferon

IFNAR (α/β, I)	Agonists:Albinterferon Interferon alpha (interferon alfa, IFN-α) Interferon alfa (IFNA1,IFNA2,IFNA4,IFNA5,IFNA6,IFNA7,IFNA8,IFNA10,IFNA13,IFNA14,IFNA16,IFNA17,IFNA21) Interferon alfa 2a Interferon alfa 2b Interferon alfa n1 Interferon alfacon-1 Interferon alpha-n3 Interferon beta (IFN-β) (IFNB1,IFNB3) Interferon beta 1a Interferon beta 1b Interferon kappa (IFN-ε/κ/τ/ζ, IFNK) Interferon omega (IFN-ω, IFNW1) Peginterferon alfa-2a Peginterferon alfa-2b Antibodies:Anifrolumab Faralimomab MEDI-545 Rontalizumab Sifalimumab Decoy receptors:Bifarcept
IFNGR (γ, II)	Agonists:Interferon gamma (IFN-γ) Interferon gamma 1b Antibodies:Emapalumab Fontolizumab
IFNLR (λ, III)	See IL-28R (IFNLR)here instead.

Interleukin

Seehere instead.

TGFβ

Seehere instead.

TNF

Seehere instead.

Others

JAK
(inhibitors)

JAK1	Abrocitinib Baricitinib Deuruxolitinib Filgotinib Momelotinib Oclacitinib Peficitinib Ruxolitinib Tofacitinib (tasocitinib) Upadacitinib
JAK2	Atiprimod AZD-1480 Baricitinib CHZ868 Cucurbitacin I (elatericin B, JSI-124) CYT387 Deuruxolitinib Lestaurtinib NSC-7908 NSC-33994 Pacritinib Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib)
JAK3	Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P 154 ZM-39923 ZM-449829
TYK2	Deucravacitinib