The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bindinterleukin 2. The low affinity form is a monomer of the alpha subunit (also calledCD25) and is not involved in signal transduction. The intermediate affinity form consists of a gamma/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved inreceptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.[5]
This protein also forms one of the three subunits of theIL-15 receptor.
Activation of the receptor increases proliferation of CD8+ effectorT cells.[6]
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^Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN (November 1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits".Science.266 (5187):1045–7.Bibcode:1994Sci...266.1045M.doi:10.1126/science.7973659.PMID7973659.
Ellery JM, Nicholls PJ (2002). "Alternate signalling pathways from the interleukin-2 receptor".Cytokine Growth Factor Rev.13 (1):27–40.doi:10.1016/S1359-6101(01)00023-5.PMID11750878.
Purvis SF, Georges DL, Williams TM, Lederman MM (1992). "Suppression of interleukin-2 and interleukin-2 receptor expression in Jurkat cells stably expressing the human immunodeficiency virus Tat protein".Cell. Immunol.144 (1):32–42.doi:10.1016/0008-8749(92)90223-C.PMID1394441.
Hatakeyama M, Kono T, Kobayashi N, Kawahara A, Levin SD, Perlmutter RM, Taniguchi T (1991). "Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association".Science.252 (5012):1523–8.Bibcode:1991Sci...252.1523H.doi:10.1126/science.2047859.PMID2047859.S2CID41503548.
Hatakeyama M, Tsudo M, Minamoto S, Kono T, Doi T, Miyata T, Miyasaka M, Taniguchi T (1989). "Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's".Science.244 (4904):551–6.Bibcode:1989Sci...244..551H.doi:10.1126/science.2785715.PMID2785715.
Puri RK, Leland P, Aggarwal BB (1995). "Constitutive expression of human immunodeficiency virus type 1 tat gene inhibits interleukin 2 and interleukin 2 receptor expression in a human CD4+ T lymphoid (H9) cell line".AIDS Res. Hum. Retroviruses.11 (1):31–40.doi:10.1089/aid.1995.11.31.PMID7734194.
