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IL18BP

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens
IL18BP
Identifiers
AliasesIL18BP, IL18BPa, interleukin 18 binding protein, FVH
External IDsOMIM:604113;MGI:1333800;HomoloGene:7781;GeneCards:IL18BP;OMA:IL18BP - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for IL18BP
Genomic location for IL18BP
Band11q13.4Start71,998,613bp[1]
End72,005,715bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for IL18BP
Genomic location for IL18BP
Band7|7 E2Start101,664,092bp[2]
End101,667,897bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • spleen

  • upper lobe of left lung

  • granulocyte

  • mucosa of ileum

  • apex of heart

  • lymph node

  • right adrenal gland

  • left adrenal cortex

  • right lung

  • right adrenal cortex
Top expressed in
  • granulocyte

  • mesenteric lymph nodes

  • seminal vesicula

  • thymus

  • mucous cell of stomach

  • tail of embryo

  • liver

  • stroma of bone marrow

  • genital tubercle

  • fetal liver hematopoietic progenitor cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10068

16068

Ensembl

ENSG00000137496

ENSMUSG00000070427

UniProt

O95998

Q9Z0M9

RefSeq (mRNA)
NM_001039659
NM_001039660
NM_001145055
NM_001145057
NM_005699

NM_173042
NM_173043
NM_173044

NM_010531
NM_001363982
NM_001382458

RefSeq (protein)
NP_001034748
NP_001034749
NP_001138527
NP_001138529
NP_005690

NP_766630
NP_766632
NP_766632.2

NP_034661
NP_001350911
NP_001369387

Location (UCSC)Chr 11: 72 – 72.01 MbChr 7: 101.66 – 101.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin-18-binding protein is aprotein that in humans is encoded by theIL18BPgene.[5][6]

The protein encoded by this gene is an inhibitor of the proinflammatorycytokineIL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Three transcript variants encoding the same protein have been found for this gene.[6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000137496 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000070427 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M (Mar 1999)."Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response".Immunity.10 (1):127–36.doi:10.1016/S1074-7613(00)80013-8.PMID 10023777.
  6. ^ab"Entrez Gene: IL18BP interleukin 18 binding protein".

Further reading

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External links

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IL-1
IL-2
IL-3
IL-4
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IL-6
IL-7
IL-8
  • See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)here instead.
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IL-13
IL-15
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IL-18
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IL1RL1
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