This gene encodes a member of the Ikaros family ofzinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) arehematopoietic-specifictranscription factors involved in the regulation oflymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate inchromatin remodeling. The regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.[7]
^Hosokawa Y, Maeda Y, Takahashi EI, Suzuki M, Seto M (November 1999). "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping".Genomics.61 (3):326–9.doi:10.1006/geno.1999.5949.PMID10552935.
Sun J, Matthias G, Mihatsch MJ, Georgopoulos K, Matthias P (February 2003). "Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice".Journal of Immunology.170 (4):1699–706.doi:10.4049/jimmunol.170.4.1699.PMID12574333.S2CID31136931.
Schmitt C, Tonnelle C, Dalloul A, Chabannon C, Debré P, Rebollo A (June 2002). "Aiolos and Ikaros: regulators of lymphocyte development, homeostasis and lymphoproliferation".Apoptosis.7 (3):277–84.doi:10.1023/A:1015372322419.PMID11997672.S2CID1318582.
Liippo J, Nera KP, Veistinen E, Lähdesmäki A, Postila V, Kimby E, Riikonen P, Hammarström L, Pelkonen J, Lassila O (December 2001). "Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene".European Journal of Immunology.31 (12):3469–74.doi:10.1002/1521-4141(200112)31:12<3469::AID-IMMU3469>3.0.CO;2-G.PMID11745366.S2CID44722991.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437 (7062):1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID16189514.S2CID4427026.
