Protein-coding gene in the species Homo sapiens
Immunoglobulin superfamily member 8 is aprotein that in humans is encoded by theIGSF8 gene .[ 5] [ 6] [ 7] CD316 (cluster of differentiation 316). IGSF8 is an innateimmune checkpoint that inhibits thecytotoxic activity ofnatural killer (NK) cells.[ 8] KIR3DL2 (or, in mice, the analogousKlra9 receptor).[ 8] [ 8] [ 9] central nervous system .[ 8]
IGSF8 as a Cancer Biomarker [ edit ] In gliomas, IGSF8 is strongly correlated with tumor grade and is a potential prognostic marker.[ 9] ovarian cancer -derivedextracellular vesicles and is a potential biomarker for the early detection of high grade serous ovarian cancer.[ 10]
^a b c GRCh38: Ensembl release 89: ENSG00000162729 –Ensembl , May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000038034 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ Stipp CS, Kolesnikova TV, Hemler ME (Oct 2001)."EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily" .J Biol Chem .276 (44):40545– 54.doi :10.1074/jbc.M107338200 PMID 11504738 . ^ Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC (Oct 2001)."PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins" .J Immunol .167 (9):5115– 21.doi :10.4049/jimmunol.167.9.5115 PMID 11673522 . ^ "Entrez Gene: IGSF8 immunoglobulin superfamily, member 8" .^a b c d Li, Yulong; Wu, Xiangyang; Sheng, Caibin; Liu, Hailing; Liu, Huizhu; Tang, Yixuan; Liu, Chao; Ding, Qingyang; Xie, Bin; Xiao, Xi; Zheng, Rongbin; Yu, Quan; Guo, Zengdan; Ma, Jian; Wang, Jin (May 2024)."IGSF8 is an innate immune checkpoint and cancer immunotherapy target" .Cell .187 (11): 2703–2716.e23.doi :10.1016/j.cell.2024.03.039 .ISSN 0092-8674 .PMID 38657602 . ^a b Ren, Jiaxing; Huang, Ping; Wang, Fei (September 2024)."IGSF8 is a potential target for the treatment of gliomas" .Asian Journal of Surgery .47 (9):3883– 3891.doi :10.1016/j.asjsur.2024.02.118 ^ Trinidad, Camille V.; Pathak, Harsh B.; Cheng, Shibo; Tzeng, Shin-Cheng; Madan, Rashna; Sardiu, Mihaela E.; Bantis, Leonidas E.; Deighan, Clayton; Jewell, Andrea; Rayamajhi, Sagar; Zeng, Yong; Godwin, Andrew K. (2023-10-26)."Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer" .Scientific Reports .13 (1): 18341.Bibcode :2023NatSR..1318341T .doi :10.1038/s41598-023-44050-5 .ISSN 2045-2322 .PMC 10603107 PMID 37884576 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" .Proc. Natl. Acad. Sci. U.S.A .99 (26):16899– 903.Bibcode :2002PNAS...9916899M .doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Charrin S, Le Naour F, Labas V, et al. (2003)."EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells" .Biochem. J .373 (Pt 2):409– 21.doi :10.1042/BJ20030343 .PMC 1223506 PMID 12708969 . Zhang XA, Lane WS, Charrin S, et al. (2003). "EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells".Cancer Res .63 (10):2665– 74.PMID 12750295 . Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes".Br. J. Dermatol .148 (4):654– 64.doi :10.1046/j.1365-2133.2003.05244.x .PMID 12752121 .S2CID 21635573 . Stipp CS, Kolesnikova TV, Hemler ME (2004)."EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5" .J. Cell Biol .163 (5):1167– 77.doi :10.1083/jcb.200309113 .PMC 2173626 PMID 14662754 . Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs" .Nat. Genet .36 (1):40– 5.doi :10.1038/ng1285 PMID 14702039 . Kolesnikova TV, Stipp CS, Rao RM, et al. (2004)."EWI-2 modulates lymphocyte integrin alpha4beta1 functions" .Blood .103 (8):3013– 9.doi :10.1182/blood-2003-07-2201 PMID 15070678 . Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" .Genome Res .14 (10B):2121– 7.doi :10.1101/gr.2596504 .PMC 528928 PMID 15489334 . Yang XH, Kovalenko OV, Kolesnikova TV, et al. (2006)."Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization" .J. Biol. Chem .281 (18):12976– 85.doi :10.1074/jbc.M510617200 PMID 16537545 . Sala-Valdés M, Ursa A, Charrin S, et al. (2006)."EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins" .J. Biol. Chem .281 (28):19665– 75.doi :10.1074/jbc.M602116200 PMID 16690612 . Kettner S, Kalthoff F, Graf P, et al. (2007)."EWI-2/CD316 is an inducible receptor of HSPA8 on human dendritic cells" .Mol. Cell. Biol .27 (21):7718– 26.doi :10.1128/MCB.00180-07 .PMC 2169036 PMID 17785435 .
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