Immunoglobulin lambda-like polypeptide 1 is aprotein that in humans is encoded by theIGLL1gene.[5][6][7] IGLL1 has also recently been designatedCD179B (cluster of differentiation 179B).
The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.[7]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Bauer SR, Huebner K, Budarf M, Finan J, Erikson J, Emanuel BS, Nowell PC, Croce CM, Melchers F (Nov 1988). "The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments".Immunogenetics.28 (5):328–33.doi:10.1007/BF00364231.PMID3139558.S2CID6981867.
^Schiff C, Milili M, Fougereau M (Dec 1989). "Isolation of early immunoglobulin lambda-like gene transcripts in human fetal liver".Eur J Immunol.19 (10):1873–8.doi:10.1002/eji.1830191018.PMID2511029.S2CID84544002.
Bossy D, Milili M, Zucman J, et al. (1992). "Organization and expression of the lambda-like genes that contribute to the mu-psi light chain complex in human pre-B cells".Int. Immunol.3 (11):1081–90.doi:10.1093/intimm/3.11.1081.PMID1760403.
Mattei MG, Fumoux F, Roeckel N, et al. (1991). "The human pre-B-specific lambda-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgC lambda locus".Genomics.9 (3):544–6.doi:10.1016/0888-7543(91)90422-B.PMID1903358.
Schiff C, Bensmana M, Guglielmi P, et al. (1991). "The immunoglobulin lambda-like gene cluster (14.1, 16.1 and F lambda 1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse lambda 5 gene".Int. Immunol.2 (3):201–7.doi:10.1093/intimm/2.3.201.PMID2128466.
Corper AL, Sohi MK, Bonagura VR, et al. (1997). "Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction".Nat. Struct. Biol.4 (5):374–81.doi:10.1038/nsb0597-374.PMID9145108.S2CID34331252.
Nomura K, Kanegane H, Karasuyama H, et al. (2000). "Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway".Blood.96 (2):610–7.PMID10887125.
