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IGFBP2

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
IGFBP2
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

2H7T

Identifiers
AliasesIGFBP2, IBP2, IGF-BP53, insulin like growth factor binding protein 2
External IDsOMIM:146731;MGI:96437;HomoloGene:499;GeneCards:IGFBP2;OMA:IGFBP2 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for IGFBP2
Genomic location for IGFBP2
Band2q35Start216,632,828bp[1]
End216,664,436bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for IGFBP2
Genomic location for IGFBP2
Band1 C3|1 36.94 cMStart72,863,662bp[2]
End72,891,633bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Descending thoracic aorta

  • ascending aorta

  • decidua

  • right coronary artery

  • body of stomach

  • ventricular zone

  • ganglionic eminence

  • olfactory zone of nasal mucosa

  • epithelium of bronchus

  • bronchial epithelial cell
Top expressed in
  • choroid plexus of fourth ventricle

  • calvaria

  • vestibular sensory epithelium

  • Epithelium of choroid plexus

  • corneal stroma

  • efferent ductule

  • optic nerve

  • transitional epithelium of urinary bladder

  • left lobe of liver

  • molar
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3485

16008

Ensembl

ENSG00000115457

ENSMUSG00000039323

UniProt

P18065

P47877

RefSeq (mRNA)

NM_001313990
NM_001313992
NM_001313993
NM_000597

NM_008342
NM_001310659

RefSeq (protein)

NP_000588
NP_001300919
NP_001300921
NP_001300922

NP_001297588
NP_032368

Location (UCSC)Chr 2: 216.63 – 216.66 MbChr 1: 72.86 – 72.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Insulin-like growth factor-binding protein 2 is aprotein that in humans is encoded by theIGFBP2gene.[5]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000115457Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000039323Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Zapf J, Kiefer M, Merryweather J, Musiarz F, Bauer D, Born W, Fischer JA, Froesch ER (Oct 1990)."Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia".J Biol Chem.265 (25):14892–8.doi:10.1016/S0021-9258(18)77200-1.PMID 1697583.

Further reading

[edit]
PDB gallery
  • 2h7t: Solution Structure of the C-terminal Domain of Insulin-like Growth Factor Binding Protein 2 (IGFBP-2)
    2h7t: Solution Structure of the C-terminal Domain of Insulin-like Growth Factor Binding Protein 2 (IGFBP-2)
Fatty acid
Hormone
Metal/element
Vitamin
Pigment
Other
Angiopoietin
CNTF
EGF (ErbB)
EGF
(ErbB1/HER1)
ErbB2/HER2
ErbB3/HER3
ErbB4/HER4
FGF
FGFR1
FGFR2
FGFR3
FGFR4
Unsorted
HGF (c-Met)
IGF
IGF-1
IGF-2
Others
LNGF (p75NTR)
PDGF
RET (GFL)
GFRα1
GFRα2
GFRα3
GFRα4
Unsorted
SCF (c-Kit)
TGFβ
Trk
TrkA
TrkB
TrkC
VEGF
Others
Stub icon

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