Protein-coding gene in the species Homo sapiens
Interferon-alpha/beta receptor beta chain is aprotein that in humans is encoded by theIFNAR2 gene .[ 5]
The protein encoded by this gene is atype I membrane protein that forms one of the two chains of areceptor for interferons alpha and beta . Binding and activation of the receptor stimulatesJanus protein kinases , which in turn phosphorylate several proteins, includingSTAT1 andSTAT2 . Multiple transcript variants encoding at least two different isoforms have been found for this gene.[ 6]
IFNAR2 has been shown tointeract with:
^a b c GRCh38: Ensembl release 89: ENSG00000159110 –Ensembl , May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000022971 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ Novick D, Cohen B, Rubinstein M (June 1994). "The human interferon alpha/beta receptor: characterization and molecular cloning".Cell .77 (3):391– 400.doi :10.1016/0092-8674(94)90154-6 .PMID 8181059 .S2CID 140206806 . ^ "Entrez Gene: IFNAR2 interferon (alpha, beta and omega) receptor 2" .^a b Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (June 2001)."The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor" .J. Biol. Chem .276 (25):22948– 53.doi :10.1074/jbc.M100087200 PMID 11301323 . ^ Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O (November 2000)."Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor" .J. Immunol .165 (9):5127– 32.doi :10.4049/jimmunol.165.9.5127 PMID 11046044 . ^ Piehler J, Schreiber G (May 1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2".J. Mol. Biol .289 (1):57– 67.doi :10.1006/jmbi.1999.2726 .PMID 10339405 . ^a b Li X, Leung S, Kerr IM, Stark GR (April 1997)."Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling" .Mol. Cell. 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Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor" .J. Biol. Chem .271 (39):23630– 3.doi :10.1074/jbc.271.39.23630 PMID 8798579 . Bonaldo MF, Lennon G, Soares MB (1996)."Normalization and subtraction: two approaches to facilitate gene discovery" .Genome Res .6 (9):791– 806.doi :10.1101/gr.6.9.791 PMID 8889548 . Croze E, Russell-Harde D, Wagner TC, Pu H, Pfeffer LM, Perez HD (1996)."The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein" .J. Biol. Chem .271 (52):33165– 8.doi :10.1074/jbc.271.52.33165 PMID 8969169 . Li X, Leung S, Kerr IM, Stark GR (1997)."Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling" .Mol. Cell. Biol .17 (4):2048– 56.doi :10.1128/mcb.17.4.2048 .PMC 232052 PMID 9121453 . Piehler J, Schreiber G (1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2".J. Mol. Biol .289 (1):57– 67.doi :10.1006/jmbi.1999.2726 .PMID 10339405 . Chuntharapai A, Gibbs V, Lu J, Ow A, Marsters S, Ashkenazi A, De Vos A, Jin Kim K (1999)."Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2" .J. Immunol .163 (2):766– 73.doi :10.4049/jimmunol.163.2.766 PMID 10395669 . 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Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O (2000)."Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor" .J. Immunol .165 (9):5127– 32.doi :10.4049/jimmunol.165.9.5127 PMID 11046044 . Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (2001)."The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor" .J. Biol. Chem .276 (25):22948– 53.doi :10.1074/jbc.M100087200 PMID 11301323 . Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ (2002)."Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling" .J. Biol. Chem .277 (12):9713– 21.doi :10.1074/jbc.M111161200 PMID 11786546 . Chill JH, Nivasch R, Levy R, Albeck S, Schreiber G, Anglister J (2002). "The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening".Biochemistry .41 (11):3575– 85.doi :10.1021/bi011778f .PMID 11888273 . Velichko S, Wagner TC, Turkson J, Jove R, Croze E (2002)."STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues" .J. Biol. Chem .277 (38):35635– 41.doi :10.1074/jbc.M204578200 PMID 12105218 . Usacheva A, Kotenko S, Witte MM, Colamonici OR (2002)."Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors" .J. Immunol .169 (3):1302– 8.doi :10.4049/jimmunol.169.3.1302 PMID 12133952 . 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PDB gallery
1n6u : NMR structure of the interferon-binding ectodomain of the human interferon receptor
1n6v : Average structure of the interferon-binding ectodomain of the human type I interferon receptor
2hym : NMR based Docking Model of the Complex between the Human Type I Interferon Receptor and Human Interferon alpha-2
