Protein-coding gene in the species Homo sapiens
Protein family
Orexin receptor type 2 (Ox2R orOX2 ), also known ashypocretin receptor type 2 (HcrtR2 ), is aprotein that in humans is encoded by theHCRTR2 gene .[ 5] CD200R1 which shares the alias OX2R but is a distinct, unrelated gene located on the human chromosome 3.[ 6]
The structure of the receptor has been solved to 2.5 Å resolution as afusion protein bound tosuvorexant using lipid-mediated crystallization.[ 7]
OX2 is aG-protein coupled receptor expressed exclusively in the brain. It has 64% identity withOX1 . OX2 binds bothorexin A and orexin B neuropeptides. OX2 is involved in the central feedback mechanism that regulates feeding behaviour.[ 5] 2 signaling are resistant to high-fat diet-induced obesity.[ 8]
This receptor is activated byHipocretin , which is a wake-promoting hypothalamic neuropeptide that acts as a critical regulator of sleep in animals asZebrafish orMammals . This protein has mutations inAstyanax mexicanus that reduces the sleep needs of the cavefish.[ 9]
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