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| Hypertelorism | |
|---|---|
| Other names | Ocular hypertelorism,[1] orbital hypertelorism,[1] hypertelorbitism[2] |
 | |
| Hypertelorism as seen inWaardenburg syndrome | |
| Specialty | Medical genetics  |
| Symptoms | Abnormally widely-spaced eyes |
| Usual onset | Congenital |
Hypertelorism is an abnormally increased distance between two organs or bodily parts, usually referring to an increased distance between the orbits (eyes), or orbital hypertelorism. In this condition, the distance between the inner eye corners, as well as the distance between the pupils, is greater than normal. Hypertelorism should not be confused withtelecanthus, in which the distance between the inner eye corners is increased, but the distances between the outer eye corners and the pupils remain unchanged.[3]
Hypertelorism is a symptom in a variety of syndromes, includingEdwards syndrome (trisomy 18),1q21.1 duplication syndrome,basal cell nevus syndrome,DiGeorge syndrome andLoeys–Dietz syndrome. Hypertelorism can also be seen inApert syndrome,Autism spectrum disorder,craniofrontonasal dysplasia,Trisomy X,frontonasal dysplasia,Noonan syndrome,neurofibromatosis,[4]LEOPARD syndrome,Pfeiffer Syndrome,Jacobsen Syndrome,Crouzon syndrome,Wolf–Hirschhorn syndrome,Andersen–Tawil syndrome,Waardenburg syndrome andcri du chat syndrome, along withpiebaldism, prominent inner third of the eyebrows,irises of different color,spondyloepiphyseal dysplasia,mucopolysaccharide metabolism disorders (Morquio syndrome andHurler's syndrome), deafness and also inhypothyroidism. Some links have been found between hypertelorism andattention deficit hyperactivity disorder.[citation needed]
Because hypertelorism is an anatomic condition associated with a heterogeneous group of congenital disorders, it is believed that the underlying mechanism of hypertelorism is also heterogeneous. Theories include too early ossification of the lower wings of thesphenoid, an increased space between theorbita, due to increasing width of theethmoid sinuses, field defects during the development, a nasal capsule that fails to form, leading to a failure in normal medial orbital migration and also a disturbance in the formation of the cranial base, which can be seen in syndromes like Apert and Crouzon.[3]
Thecraniofacial surgery to correct hypertelorism is usually done between five and eight years of age.[5] This aesthetic-focused procedure addresses the psychosocial aspects in the child's early school years. Another reason for a correction age of five years or older is that the surgery should be delayed until the tooth buds have grown out low enough into themaxilla, thus preventing damage to them. Also, before age five the craniofacial bones are thin and fragile, which can make surgical correction difficult. In addition, it is possible that orbital surgery during infancy may inhibit midface growth.[3]
For the treatment of hypertelorism there are two main operative options: The box osteotomy and the facial bipartition (also referred to as median fasciotomy).[6]
This treatment of orbital hypertelorism was first performed byPaul Tessier.[7] The surgery starts off by variousosteotomies that separate the entire bony part of the orbit from the skull and surrounding facial bones. One of the osteotomies consists of removing the bone between the orbits. The orbits are then mobilized and brought towards each other. Because this often creates excessive skin between the orbits a midline excision of skin is frequently necessary. This approximates the eyebrows and eye corners and provides a more pleasing look.[3]
The standard procedure (box osteotomy) was modified by Jacques van der Meulen and resulted in the development of the facial bipartition (or median fasciotomy).[8][9]Facial bipartition first involves splitting the frontal bone from the supraorbital rim. Then the orbits and the midface are released from the skull-base using monoblock osteotomy. Then a triangular shaped piece of bone is removed from the midline of the midface. The base of this triangular segment lies above the orbita and the apex lies between the upper incisor teeth. After removing this segment it is possible to rotate the two halves of the midface towards each other, thus resulting in reduction of the distance between the orbits. It also results in leveling out the V-shaped maxilla and therefore widening of it.Because hypertelorism is often associated with syndromes like Apert, hypertelorism is often seen in combination with midfacedysplasia. If this is the case, facial bipartition can be combined with distraction osteogenesis. The aim ofdistraction osteogenesis of the midface is to normalize the relationship between orbital rim to eye and also normalize the position ofzygomas, nose and maxilla in relation to themandible.[10]
To create an acceptable aesthetic result in the correction of orbital hypertelorism, it is also important to take soft-tissue reconstruction in consideration. In this context, correction of the nasal deformities is one of the more difficult procedures. Bone and cartilage grafts may be necessary to create a nasal frame and local rotation with for example forehead flaps, or advancement flaps can be used to cover the nose.[3]
As with most surgeries, the main complications in both treatments of hypertelorism include excessive bleeding, risk of infection,CSF leaks, and duralfistulas. Infections and leaks can be prevented by givingperioperative antibiotics and identifying and closing of anydural tears. The risk of significant bleeding can be prevented by meticulous technique, and blood loss can be compensated for with transfusions. Blood loss can also be reduced by giving hypotensive anesthesia. Major eye injuries, including blindness, are rarely seen. Visual disturbances can occur due to the eye muscle imbalance after orbital mobilization.Ptosis anddiplopia can also occur postoperatively, but this usually self-corrects. A complication that poses a challenge to correct postoperatively is canthal drift, which can be managed best by carefully preserving the canthal tendon attachments as much as possible. Despite the extensiveness in these procedures, mortality is rarely seen in operative correction of hypertelorism.[3]
