Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

Hydroxynefazodone

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Hydroxynefazodone
Clinical data
Other namesOH-NEF
Pharmacokinetic data
Eliminationhalf-life1.5–4 hours[1]
Identifiers
  • 2-[3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl]-5-(1-hydroxyethyl)-4-(2-phenoxyethyl)-1,2,4-triazol-3-one
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC25H32ClN5O3
Molar mass486.01 g·mol−1
3D model (JSmol)
  • CC(C1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl)O
  • InChI=1S/C25H32ClN5O3/c1-20(32)24-27-31(25(33)30(24)17-18-34-23-9-3-2-4-10-23)12-6-11-28-13-15-29(16-14-28)22-8-5-7-21(26)19-22/h2-5,7-10,19-20,32H,6,11-18H2,1H3
  • Key:VKGQYGXMUUBRBD-UHFFFAOYSA-N

Hydroxynefazodone is aphenylpiperazinecompound and a majormetabolite of theantidepressantnefazodone.[1][2][3] It has similarbiological activity and a similarelimination half-life (1.5 to 4 hours)[1] to those of nefazodone, and may contribute significantly to its effects.[2][3]

See also

[edit]

References

[edit]
  1. ^abcGolden RN, Dawkins K, Nicholas L (2017)."Trazodone and Nefazodone". In Schatzberg AF, Nemeroff CB (eds.).The American Psychiatric Association Publishing Textbook of Psychopharmacology (Fifth ed.). American Psychiatric Pub. pp. 460–.ISBN 978-1-58562-523-9.
  2. ^abPreskorn SH, Catterson ML (6 December 2012)."General Principles of Pharmacokinetics". In Preskorn SH, Stanga CY, Feighner JP, Ross R (eds.).Antidepressants: Past, Present and Future. Springer Science & Business Media. pp. 68–.ISBN 978-3-642-18500-7.
  3. ^abDavis R, Whittington R, Bryson HM (April 1997). "Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression".Drugs.53 (4):608–636.doi:10.2165/00003495-199753040-00006.PMID 9098663.S2CID 239077479.
α1
Agonists
Antagonists
α2
Agonists
Antagonists
β
Agonists
Antagonists
H1
Agonists
Antagonists
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists
DATTooltip Dopamine transporter
(DRIsTooltip Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter
(NRIsTooltip Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter
(SRIsTooltip Serotonin reuptake inhibitors)
VMATsTooltip Vesicular monoamine transporters
Others
5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT3–7
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7
Stub icon

Thisdrug article relating to thenervous system is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Hydroxynefazodone&oldid=1248751547"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2025 Movatter.jp