 | |
| Names | |
|---|---|
| IUPAC name (5R)-5-Hydroxy-L-lysine | |
| Systematic IUPAC name (2S,5R)-2,6-Diamino-5-hydroxyhexanoic acid | |
Other names
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| Identifiers | |
3D model (JSmol) | |
| ChemSpider |
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| ECHA InfoCard | 100.013.388 |
| KEGG |
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| MeSH | Hydroxylysine |
| UNII | |
| |
| |
| Properties | |
| C6H14N2O3 | |
| Molar mass | 162.189 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Hydroxylysine (Hyl) is anamino acid with the molecular formula C6H14N2O3. It was first discovered in 1921 byDonald Van Slyke as the 5-hydroxylysine form.[1] It arises from a post-translationalhydroxy modification oflysine. It is most widely known as a component ofcollagen.[2]
It is biosynthesized from lysine via oxidation bylysyl hydroxylase enzymes. The most common form is the (5R) stereoisomer found in collagen. However, the enzyme JMJD6 has recently been shown to be a lysyl hydroxylase which modifies an RNA splicing factor producing the (5S) stereoisomer. Additionally, inE. coli, there has been at least one lysineN-hydroxylase enzyme identified, named IucD.[3]
