Humberto Ramos began his career in 1989 at Kaboom Cómics. He was later hired byDC Comics as the regular penciller for theirFlash spin-offImpulse, which launched in March 1995.[2] Written byMark Waid, the superhero/teen comedy series focused on young speedsterBart Allen, the grandson of the second Flash,Barry Allen, and his struggles with growing up inManchester, Alabama.
In 1998, Ramos co-founded the imprintCliffhanger with comic book artistsJoe Madureira andJ. Scott Campbell. They created the imprint, housed byJim Lee'sImage Comics divisionWildstorm, to publish their creator-owned comic books outside the mainstream superhero genre. Both Campbell and Madureira had already built large fanbases with their previous work onGen13 andUncanny X-Men respectively, and were two of the most popular comic book artists at the time. Ramos, on the other hand, was not as popular and his inclusion on the imprint was perceived as second choice, after fan-favoriteMichael Turner declined because he was still under contract atTop Cow.[3] Ramos' first Cliffhanger titleCrimson ran for 24 issues and two one-shots, with poor success. It was followed by thefantasy/mystery seriesOut There, months later. Ramos also began illustrating the covers ofPeter Parker: Spider-Man with issue #30 and—beginning with May 2002'sPeter Parker: Spider-Man #44—additionally did the interior artwork on the four-issue story arc "A Death in the Family" (later collected asSpider-Man: Return of the Goblin;ISBN0-7851-1019-4), written byPaul Jenkins.
After his Cliffhanger contract expired, andOut There concluded after 18 issues in early 2003, Ramos left the imprint, apparently not on the best terms,[4] and launched a newSpider-Man title,The Spectacular Spider-Man. The book reunited Ramos withPeter Parker: Spider-Man writer Paul Jenkins and earned him a 2005Harvey Award nomination as Best Cover Artist. While Ramos worked onSpectacular Spider-Man, another book created by him (although illustrated by Francisco Herrera), the six-issue miniseriesKamikaze, which had originally been planned for 2001,[5] was published by WildStorm under the Cliffhanger imprint.
In 2005, Ramos' creator-owned six-issue miniseriesRevelations began publication byDark Horse Comics.[5]
FollowingRevelations, Ramos returned to Marvel Comics, joining writerMarc Guggenheim as the new creative team onWolverine, beginning with issue #42 in March 2006.[6] The same month also saw the release of the first volume of thespace operaKookaburra K, a series of three 46-pagecomic albums Ramos illustrated for French comic publisherSoleil Productions, written by French comic book creatorCrisse.
In April 2014, Ramos and writerDan Slott launchedThe Amazing Spider-Man as part ofMarvel NOW!. The first issue of this new version ofThe Amazing Spider-Man is, according to Diamond Comics Distributors, "The Best Selling Comic of the 21st Century."[7] In 2016, Ramos and writerMark Waid co-createdThe Champions for Marvel.