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AHFS/Drugs.com | Monograph |
MedlinePlus | a601006 |
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ECHA InfoCard | 100.001.561![]() |
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Formula | C16H21NO3 |
Molar mass | 275.348 g·mol−1 |
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Homatropine (Equipin,Isopto Homatropine) is ananticholinergicmedication that is an antagonist atmuscarinic acetylcholine receptors and thus theparasympathetic nervous system. It is used ineye drops as acycloplegic (to temporarily paralyzeaccommodation), and as amydriatic (to dilate thepupil).
The related chemical compoundhomatropine methylbromide (methylhomatropine) is a different medication. Homatropine is lesspotent thanatropine and has a shorter duration of action. It is available as thehydrobromidesalt. Homatropine is also given as an atropine substitute,[1] given to reverse the muscarinic andCNS effects associated with indirectcholinomimetic (anti-AChase) administration.
Homatropine hydrobromide is on theWorld Health Organization's List of Essential Medicines.[2]
It is an antagonist of all five muscarinic acetylcholine receptors.[3]
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