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Homatropine

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Medication
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Pharmaceutical compound
Homatropine
Clinical data
AHFS/Drugs.comMonograph
MedlinePlusa601006
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • (N-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.001.561Edit this at Wikidata
Chemical and physical data
FormulaC16H21NO3
Molar mass275.348 g·mol−1
3D model (JSmol)
  • CN3[C@H]1CC[C@@H]3C[C@@H](C1)OC(=O)C(O)c2ccccc2
  • InChI=1S/C16H21NO3/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11/h2-6,12-15,18H,7-10H2,1H3/t12-,13+,14+,15? checkY
  • Key:ZTVIKZXZYLEVOL-MCOXGKPRSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Homatropine (Equipin,Isopto Homatropine) is ananticholinergicmedication that is an antagonist atmuscarinic acetylcholine receptors and thus theparasympathetic nervous system. It is used ineye drops as acycloplegic (to temporarily paralyzeaccommodation), and as amydriatic (to dilate thepupil).

The related chemical compoundhomatropine methylbromide (methylhomatropine) is a different medication. Homatropine is lesspotent thanatropine and has a shorter duration of action. It is available as thehydrobromidesalt. Homatropine is also given as an atropine substitute,[1] given to reverse the muscarinic andCNS effects associated with indirectcholinomimetic (anti-AChase) administration.

Homatropine hydrobromide is on theWorld Health Organization's List of Essential Medicines.[2]

It is an antagonist of all five muscarinic acetylcholine receptors.[3]

Side effects

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Contraindications

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References

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  1. ^Scharer LL, Burhenne HJ (April 1964). "Megacolon associated with administration of an anticholinergic drug in a patient with ulcerative colitis".The American Journal of Digestive Diseases.9 (4):268–274.doi:10.1007/bf02232133.PMID 14142388.S2CID 19169565.
  2. ^World Health Organization (2023).The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization.hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  3. ^Lavrador M, Cabral AC, Veríssimo MT, Fernandez-Llimos F, Figueiredo IV, Castel-Branco MM (January 2023)."A Universal Pharmacological-Based List of Drugs with Anticholinergic Activity".Pharmaceutics.15 (1): 230.doi:10.3390/pharmaceutics15010230.PMC 9863833.PMID 36678858.
Anticholinergics/antimuscarinics
Sympathomimetics
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(andprodrugs)


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