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| Formula | C33H38N6 |
| Molar mass | 518.709 g·mol−1 |
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Hodgkinsine is analkaloid found in plants of the genusPsychotria, particularlyPsychotria colorata,[1] although it is also found inPsychotria lyciiflora[2] and probably other species in this family,[3]
Hodgkinsine hasantiviral, antibacterial and antifungal effects, but has mainly been researched for theanalgesic effects that it produces, and is thought to be one of the components responsible for the analgesic effects seen whenPsychotria colorata is used in traditional medical practice in humans. It has been found to act as both amu opioid agonist and anNMDA antagonist,[4] both of which are mechanisms of action shared with commonly used painkillers (morphine andketamine respectively, and which occur concurrently in the clinical analgesicsmethadone andlevorphanol).
Hodgkinsine is atrimer composed of three pyrrolidinoindoline subunits, with themonomer closely resembling another alkaloideseroline which has similar bioactivity. Due to its complex structure and multiple chiral centres, hodgkinsine has manystereoisomers and significant research has been undertaken to elucidate the structure-activity relationships of the various isomers and synthetic derivatives structurally derived from hodgkinsine.[5][6][7]
