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Hexolame

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Hexolame
Clinical data
Other names17β-((6-Hydroxyhexyl)amino)estradiol; 17β-[(6-Hydroxyhexyl)amino]estra-1,3,5(10)-trien-3-ol; N-(3-Hydroxy-1,3,5(10)-estratrien 17-yl)-6-hydroxyhexylamine
Identifiers
  • (8R,9S,13S,14S,17S)-17-(6-Hydroxyhexylamino)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC24H37NO2
Molar mass371.565 g·mol−1
3D model (JSmol)
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2NCCCCCCO)CCC4=C3C=CC(=C4)O
  • InChI=1S/C24H37NO2/c1-24-13-12-20-19-9-7-18(27)16-17(19)6-8-21(20)22(24)10-11-23(24)25-14-4-2-3-5-15-26/h7,9,16,20-23,25-27H,2-6,8,10-15H2,1H3/t20-,21-,22+,23+,24+/m1/s1
  • Key:DPRSBWGNESQTLG-DJCPXJLLSA-N

Hexolame, also known as17β-((6-hydroxyhexyl)amino)estradiol, is asynthetic,steroidalestrogen and a17β-aminoestrogen withanticoagulant effects that was first described in 1990 and was never marketed.[1][2][3]

References

[edit]
  1. ^Negwer M, Scharnow HG (2001).Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. p. 12610.ISBN 978-3-527-30247-5.
  2. ^Rubio-Póo C, Lemini C, García-Mondragón J, de la Peña A, Jayme V, Mendoza-Patiño N, et al. (February 1990). "The anticoagulant effect of hexolame, N-(3-hydroxy-1,3,5(10)-estratrien-17 beta-yl)-6-hydroxyhexylamine, another amino-estrogen with prolonged anticoagulant effect".Steroids.55 (2):83–86.doi:10.1016/0039-128x(90)90030-f.PMID 2326832.S2CID 32937513.
  3. ^Rubio-Póo C, Lemini C, Silva G, García-Mondragón J, Zavala E, Castro D, et al. (1993). "Comparison of the time course of anticoagulant and estrogenic effects of prolame, butolame, pentolame and hexolame, a homologous series of 17 beta-amino estrogens".Proceedings of the Western Pharmacology Society.36:143–147.PMID 8378368.
ERTooltip Estrogen receptor
Agonists
Mixed
(SERMsTooltip Selective estrogen receptor modulators)
Antagonists
GPERTooltip G protein-coupled estrogen receptor
Agonists
Antagonists
Unknown

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