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Harry F. Noller

From Wikipedia, the free encyclopedia
American biochemist (born 1939)
Harry F. Noller
BornJune 10, 1939 (1939-06-10) (age 86)
Alma materUniversity of California, Berkeley,University of Oregon
Known forRibosome structural and functional determination
AwardsPaul Ehrlich and Ludwig Darmstaedter Prize (2006)
Gairdner Foundation International Award (2007)
Breakthrough Prize (2016)
Scientific career
FieldsBiochemistry
InstitutionsUniversity of California, Santa Cruz

Harry F. Noller (born June 10, 1939[citation needed]) is an Americanbiochemist, and since 1992 the director of the University of California, Santa Cruz'sCenter for the Molecular Biology of RNA. He has made significant contributions to our understanding of theribosome and is a member of theNational Academy of Sciences.

Early life and education

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Noller is a native ofOakland, California.[1] He earned his B.S. degree in biochemistry at theUniversity of California, Berkeley in 1960[2] and his Ph.D. in chemistry from theUniversity of Oregon[3] in 1965.[2]He carried out post-doctoral work at theMedical Research Council Laboratory of Molecular Biology in Cambridge and the Institute of Molecular Biology at theUniversity of Geneva.[1]

Scientific contributions and honors

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Noller joined the faculty at University of California, Santa Cruz in 1968.[3] In his decades-long study of the moleculartranslational machinery of the cell, he has made fundamental contributions in understanding the structure and function of the cell's protein-synthesis factory, theribosome. Notable amongst these contributions are having demonstrated that the ribosome is aribozyme and leading the solution of the firstcrystal structures atmolecularresolution for complete ribosomes.[4][5][6]

Noller was elected to theNational Academy of Sciences in 1992.[3] He has been recognized with prizes from thePaul Ehrlich Foundation in 2006 and theGairdner Foundation in 2007, each of which was shared with eventual winners of theNobel Prize in Chemistry for 2009.[1][7] He won aBreakthrough Prize in 2016.[8]

References

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  1. ^abc"Harry F. Noller, Ph.D." The Gairdner Awards. Archived fromthe original on 1 August 2009. Retrieved11 January 2011.
  2. ^abSoo Hoo Lee (2013-12-01)."Harry F. Nollder's Reflections".ASBMB Today. Archived fromthe original on 2019-11-01. Retrieved2019-02-28.
  3. ^abc"UCSC biologist Harry Noller honored by Paul Ehrlich Foundation".University News & Events. University of California. 12 December 2006. Retrieved11 January 2011.
  4. ^Noller, Harry F.; Hoffarth, Vernita; Zimniak, Ludwika (1992). "Unusual Resistance of Peptidyl Transferase to Protein Extraction Procedures".Science.256 (5062):1416–1419.Bibcode:1992Sci...256.1416N.doi:10.1126/science.1604315.PMID 1604315.
  5. ^Cate, Jamie H.; Yusupov, Marat M.; Yusupova, Gulnara Zh.; Earnest, Thomas N.; Noller, Harry F. (1999). "X-ray Crystal Structures of 70S Ribosome Functional Complexes".Science.285 (5436):2095–2104.doi:10.1126/science.285.5436.2095.PMID 10497122.
  6. ^Yusupov, Marat M.; Yusupova, Gulnara Zh.; Baucom, Albion; Lieberman, Kate; Earnest, Thomas N.; Cate, J. H. D.; Noller, Harry F. (2001). "Crystal Structure of the Ribosome at 5.5 Å Resolution".Science.292 (5518):883–896.Bibcode:2001Sci...292..883Y.doi:10.1126/science.1060089.PMID 11283358.
  7. ^Nicholson, Josh (May 24, 2007)."Harry Noller Wins Award for Ribosome Work".City on a Hill Press. Retrieved11 January 2011.
  8. ^"5 top scientists win Breakthrough Prizes in star-studded event". 5 December 2016.

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