American biochemist (born 1939)
Harry F. Noller (born June 10, 1939[citation needed ] ) is an Americanbiochemist , and since 1992 the director of the University of California, Santa Cruz's Center for the Molecular Biology of RNA . He has made significant contributions to our understanding of theribosome and is a member of theNational Academy of Sciences .
Early life and education [ edit ] Noller is a native ofOakland, California .[ 1] He earned his B.S. degree in biochemistry at theUniversity of California, Berkeley in 1960[ 2] and his Ph.D. in chemistry from theUniversity of Oregon [ 3] in 1965.[ 2] He carried out post-doctoral work at theMedical Research Council Laboratory of Molecular Biology in Cambridge and the Institute of Molecular Biology at theUniversity of Geneva .[ 1]
Scientific contributions and honors [ edit ] Noller joined the faculty at University of California, Santa Cruz in 1968.[ 3] In his decades-long study of the moleculartranslational machinery of the cell, he has made fundamental contributions in understanding the structure and function of the cell's protein-synthesis factory, theribosome . Notable amongst these contributions are having demonstrated that the ribosome is aribozyme and leading the solution of the firstcrystal structures atmolecular resolution for complete ribosomes.[ 4] [ 5] [ 6]
Noller was elected to theNational Academy of Sciences in 1992.[ 3] He has been recognized with prizes from thePaul Ehrlich Foundation in 2006 and theGairdner Foundation in 2007, each of which was shared with eventual winners of theNobel Prize in Chemistry for 2009.[ 1] [ 7] He won aBreakthrough Prize in 2016.[ 8]
^a b c "Harry F. Noller, Ph.D." The Gairdner Awards. Archived fromthe original on 1 August 2009. Retrieved11 January 2011 .^a b Soo Hoo Lee (2013-12-01)."Harry F. Nollder's Reflections" .ASBMB Today . Archived fromthe original on 2019-11-01. Retrieved2019-02-28 . ^a b c "UCSC biologist Harry Noller honored by Paul Ehrlich Foundation" .University News & Events . University of California. 12 December 2006. Retrieved11 January 2011 .^ Noller, Harry F.; Hoffarth, Vernita; Zimniak, Ludwika (1992). "Unusual Resistance of Peptidyl Transferase to Protein Extraction Procedures".Science .256 (5062):1416– 1419.Bibcode :1992Sci...256.1416N .doi :10.1126/science.1604315 .PMID 1604315 . ^ Cate, Jamie H.; Yusupov, Marat M.; Yusupova, Gulnara Zh.; Earnest, Thomas N.; Noller, Harry F. (1999). "X-ray Crystal Structures of 70S Ribosome Functional Complexes".Science .285 (5436):2095– 2104.doi :10.1126/science.285.5436.2095 .PMID 10497122 . ^ Yusupov, Marat M.; Yusupova, Gulnara Zh.; Baucom, Albion; Lieberman, Kate; Earnest, Thomas N.; Cate, J. H. D.; Noller, Harry F. (2001). "Crystal Structure of the Ribosome at 5.5 Å Resolution".Science .292 (5518):883– 896.Bibcode :2001Sci...292..883Y .doi :10.1126/science.1060089 .PMID 11283358 . ^ Nicholson, Josh (May 24, 2007)."Harry Noller Wins Award for Ribosome Work" .City on a Hill Press . Retrieved11 January 2011 . ^ "5 top scientists win Breakthrough Prizes in star-studded event" . 5 December 2016.
Mathematics Fundamental physics Nima Arkani-Hamed ,Alan Guth ,Alexei Kitaev ,Maxim Kontsevich ,Andrei Linde ,Juan Maldacena ,Nathan Seiberg ,Ashoke Sen ,Edward Witten (2012)Special :Stephen Hawking ,Peter Jenni ,Fabiola Gianotti (ATLAS),Michel Della Negra ,Tejinder Virdee ,Guido Tonelli ,Joseph Incandela (CMS) andLyn Evans (LHC) (2013)Alexander Polyakov (2013)Michael Green andJohn Henry Schwarz (2014)Saul Perlmutter and members of theSupernova Cosmology Project ;Brian Schmidt ,Adam Riess and members of theHigh-Z Supernova Team (2015)Special :Ronald Drever ,Kip Thorne ,Rainer Weiss and contributors toLIGO project (2016)Yifang Wang ,Kam-Biu Luk and theDaya Bay team ,Atsuto Suzuki and theKamLAND team,Kōichirō Nishikawa and theK2K /T2K team,Arthur B. McDonald and theSudbury Neutrino Observatory team,Takaaki Kajita andYōichirō Suzuki and theSuper-Kamiokande team (2016)Joseph Polchinski ,Andrew Strominger ,Cumrun Vafa (2017)Charles L. Bennett ,Gary Hinshaw ,Norman Jarosik ,Lyman Page Jr. ,David Spergel (2018)Special :Jocelyn Bell Burnell (2018)Charles Kane andEugene Mele (2019)Special :Sergio Ferrara ,Daniel Z. Freedman ,Peter van Nieuwenhuizen (2019)The Event Horizon Telescope Collaboration (2020)Eric Adelberger ,Jens H. Gundlach andBlayne Heckel (2021)Special :Steven Weinberg (2021)Hidetoshi Katori andJun Ye (2022)Charles H. Bennett ,Gilles Brassard ,David Deutsch ,Peter W. Shor (2023)John Cardy andAlexander Zamolodchikov (2024)Large Hadron Collider experiments:ATLAS team,CMS team,ALICE team,LHCb team (2025)Special :Gerard 't Hooft (2025)Life sciences Cornelia Bargmann ,David Botstein ,Lewis C. Cantley ,Hans Clevers ,Titia de Lange ,Napoleone Ferrara ,Eric Lander ,Charles Sawyers ,Robert Weinberg ,Shinya Yamanaka andBert Vogelstein (2013)James P. Allison ,Mahlon DeLong ,Michael N. Hall ,Robert S. Langer ,Richard P. Lifton andAlexander Varshavsky (2014)Alim Louis Benabid ,Charles David Allis ,Victor Ambros ,Gary Ruvkun ,Jennifer Doudna andEmmanuelle Charpentier (2015)Edward Boyden ,Karl Deisseroth ,John Hardy ,Helen Hobbs andSvante Pääbo (2016)Stephen J. Elledge ,Harry F. Noller ,Roeland Nusse ,Yoshinori Ohsumi ,Huda Zoghbi (2017)Joanne Chory ,Peter Walter ,Kazutoshi Mori ,Kim Nasmyth ,Don W. Cleveland (2018)C. Frank Bennett andAdrian R. Krainer ,Angelika Amon ,Xiaowei Zhuang ,Zhijian Chen (2019)Jeffrey M. Friedman ,Franz-Ulrich Hartl ,Arthur L. Horwich ,David Julius ,Virginia Man-Yee Lee (2020)David Baker ,Catherine Dulac ,Dennis Lo ,Richard J. Youle [de ] (2021)Jeffery W. Kelly ,Katalin Karikó ,Drew Weissman ,Shankar Balasubramanian ,David Klenerman andPascal Mayer (2022)Clifford P. Brangwynne ,Anthony A. Hyman ,Demis Hassabis ,John Jumper ,Emmanuel Mignot ,Masashi Yanagisawa (2023)Carl June ,Michel Sadelain ,Sabine Hadida ,Paul Negulescu ,Fredrick Van Goor ,Thomas Gasser ,Ellen Sidransky andAndrew Singleton (2024)
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