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Haplogroup R2

From Wikipedia, the free encyclopedia
Human Y-chromosome DNA haplogroup

Haplogroup R2
Possible time of origin27,000BP[1]
Possible place of originSouth Asia or Central Asia[1]
AncestorHaplogroup R
DescendantsR2a (M124);
R2b (FGC21706)
Defining mutationsM479

Haplogroup R2, orR-M479, is aY-chromosome haplogroup characterised bygenetic markerM479. It is one of two primary descendants ofHaplogroup R (R-M207), the other beingR1 (R-M173).

R-M479, especially its downstream R2a (R-M124), has been concentrated geographically inSouth Asia,Central Asia and parts of theMiddle East since prehistory.[2] R2 (excluding R2a) appears to reach its highest levels among theBurusho people inNorth Pakistan.[3]

R2 has much lower rates of sampling compared to itsR1 counterpart[4] with 399 branches downstream off R-M479, opposed to 46,529 for R-M173.

It has two primary branches:R2a (M124) andR2b (R-FGC21706)

Structure

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  • R (M207/Page37/UTY2)
    • R1 (M173/P241/Page29)
    • R2 (M479/PF6107, L266/PF6108, L722, L726)
      • R2a (M124, F820/Page4, L381, P249)
        • R2a1 (L263)
        • R2a2 (P267/PF6109)
      • R2b (FGC21706, FGC50198, FGC50325, FGC50333, SK2163, SK2164, SK2165, SK2166)
        • R2b1 (FGC50339)


Source: ISOGG 2017.[1]

Geographical distribution

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Most research has tested only for the presence of R-M479 (R2) and R-M124 (R2a) – or SNPs downstream from M124 like P249, P267, L266, PAGES00004, and L381 SNPs). Because the other primary branch,R2b (R-FGC21706) was discovered later than R2a, it has often not been tested for. Hence most results are best described as R2(xR2a).

In addition, relatively little research has been done within South Asia, which is known to have the greatest concentration of R2. (Hence the figures cited in the table right may not be indicative of true frequencies, i.e. Pakistan is the only South Asian country that has been included.)

In 2013, R2(xR2a) was found in 5 out of 19 males from theBurusho minority of North Pakistan.[3]

R2a (R-M124)

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Haplogroup R2a (R-M124) is characterised bySNPs M124, F820/Page4, L381, P249,[1] and is mainly found inSouth Asia, with lower frequencies inCentral Asia,Middle East and theCaucasus.[2] R-M124 is also found in multiple Jewish populations:Iraqi Jews,Persian Jews,Mountain Jews, andAshkenazi Jews.[5]

R2b (R-FGC21706/ R-FGC50231)

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It is found especially in the Indian subcontinent. On FTDNA the greatest frequency of R-FGC50231 testers originate from Pakistan, with 2% of testers being classified as R-FGC50231, additionally other prominent nations include, India, Afghanistan and Tajikistan.[6][7]

Phylogenetic tree

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M479

R2*

M124

 R2a

 FGC21706

 R2b

Description of the SNP M479

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Common Name MarkerM479
YCC HaplogroupR-M479
Nucleotide changeC to T
Amplicon size (bp) reference sequence323
Polymorphism position from 5' end107
Restriction enzyme variantHphI
RefSNP ID-
Y-position19294055
Primer forward 5'-3'gatactttatcaggcttacttc
Primer reverse 5'-3'aaccaaatctctcagaatcg

Notes

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  1. ^abcdISOGG, 2017,Y-DNA Haplogroup R and its Subclades – 2017 (17 June 2017).
  2. ^abManoukian, Jean-Grégoire (1 December 2006)."A Synthesis of Haplogroup R2"(PDF).ysearch.org. Archived fromthe original(PDF) on 27 September 2007.
  3. ^abCristofaro, Julie Di; Pennarun, Erwan; Mazières, Stéphane; Myres, Natalie M.; Lin, Alice A.; Temori, Shah Aga; Metspalu, Mait; Metspalu, Ene; Witzel, Michael; King, Roy J.; Underhill, Peter A.; Villems, Richard; Chiaroni, Jacques (2013)."Afghan Hindu Kush: Where Eurasian Sub-Continent Gene Flows Converge".PLOS ONE.8 (10) e76748.Bibcode:2013PLoSO...876748D.doi:10.1371/journal.pone.0076748.PMC 3799995.PMID 24204668.
  4. ^"FamilyTreeDNA - Genetic Testing for Ancestry, Family History & Genealogy".FamilyTreeDNA. Retrieved3 January 2026.
  5. ^Brook, Kevin Alan.The Jews of Khazaria (3rd ed.). Rowman & Littlefield. p. 185.doi:10.5040/9798881833770.ISBN 978-1-5381-0342-5.
  6. ^"R-FGC50227 YTree".YFull. Retrieved15 February 2024.
  7. ^"Welcome to FamilyTreeDNA Discover".FamilyTreeDNA. Retrieved3 January 2026.

See also

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Y-DNA R-M207 subclades

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Y-DNA backbone tree

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This article needs to beupdated. Please help update this article to reflect recent events or newly available information.(February 2021)
Footnotes
  1. ^Van Oven M, Van Geystelen A, Kayser M, Decorte R, Larmuseau HD (2014). "Seeing the wood for the trees: a minimal reference phylogeny for the human Y chromosome".Human Mutation.35 (2):187–91.doi:10.1002/humu.22468.PMID 24166809.S2CID 23291764.
  2. ^International Society of Genetic Genealogy (ISOGG; 2015),Y-DNA Haplogroup Tree 2015. (Access date: 1 February 2015.)
  3. ^Haplogroup A0-T is also known as A-L1085 (and previously as A0'1'2'3'4).
  4. ^Haplogroup A1 is also known as A1'2'3'4.
  5. ^ F-Y27277, sometimes known as F2'4, is both the parent clade of F2 and F4 and a child of F-M89.
  6. ^Haplogroup LT (L298/P326) is also known as Haplogroup K1.
  7. ^Between 2002 and 2008,Haplogroup T-M184 was known as "Haplogroup K2". That name has since been re-assigned toK-M526, the sibling of Haplogroup LT.
  8. ^ Haplogroup K2b (M1221/P331/PF5911) is also known as Haplogroup MPS.
  9. ^ Haplogroup K2b1 (P397/P399) is also known as Haplogroup MS, but has a broader and more complex internal structure.
  10. ^ Haplogroup P (P295) is also klnown as K2b2.
  11. ^K-M2313*, which as yet has no phylogenetic name, has been documented in two living individuals, who have ethnic ties to India and South East Asia. In addition, K-Y28299, which appears to be a primary branch of K-M2313, has been found in three living individuals from India. See: Poznikop. cit.;YFull YTree v5.08, 2017, "K-M2335", and;PhyloTree, 2017, "Details of the Y-SNP markers included in the minimal Y tree" (Access date of these pages: 9 December 2017)
  12. ^ Haplogroup M, as of 2017, is also known as K2b1b. (Previously the name Haplogroup M was assigned to K2b1d.)
  13. ^ Haplogroup S, as of 2017, is also known as K2b1a. (Previously the name Haplogroup S was assigned to K2b1a4.)

External links

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