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Haplogroup JT

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Human mitochondrial DNA

Haplogroup JT
Possible time of origin	50,300 YBP
Possible place of origin	West Asia
Ancestor	R2'JT
Descendants	J,T
Defining mutations	11251, 15452A, 16126^[1]

Haplogroup JT is ahuman mitochondrial DNA (mtDNA) haplogroup.

Origin

Haplogroup JT is descended from the macro-haplogroupR. It is the ancestral clade to the mitochondrial haplogroupsJ andT.

Distribution

JT (predominantlyJ) was found among the ancientEtruscans.^[2] The root level haplogroup JT* has been assigned to an ancient person found at the Colfiorito necropolis inUmbria in central Italy.^[3]

The haplogroup has also been found amongIberomaurusian specimens dating from theEpipaleolithic at theTaforalt prehistoric site.^[4] One ancient individual carried a haplotype, which correlates with either the JT clade or the haplogroupH subclade H14b1 (1/9; 11%).^[5]

Subclades

Tree

This phylogenetic tree of haplogroup JT subclades is based on the paper by Mannis van Oven and Manfred KayserUpdated comprehensive phylogenetic tree of global human mitochondrial DNA variation^[1] and subsequent published research.

R2'JT
- JT
  - J
  - T

Health

Maternally inherited ancient mtDNA variants have clear impact on the presentation of disease in a modern society. Superhaplogroup JT is an example of reduced risk of Parkinson's disease^[6] And mitochondrial and mtDNa alterations continue to be promising disease biomarkers.^[7]^[8]

See also

Phylogenetic tree ofhuman mitochondrial DNA (mtDNA) haplogroups

Mitochondrial Eve (L)

L1–6

References

^^a ^bvan Oven, Mannis; Manfred Kayser (13 Oct 2008)."Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation".Human Mutation.30 (2):E386 –E394.doi:10.1002/humu.20921.PMID 18853457.
^"We Are Not Our Ancestors". Archived fromthe original on 2009-04-08. Retrieved2012-02-10.
^GenBank Accession number: MN687309.1
^Bernard Secher; Rosa Fregel; José M Larruga; Vicente M Cabrera; Phillip Endicott; José J Pestano; Ana M González (2014)."The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents".BMC Evolutionary Biology.14 (1): 109.Bibcode:2014BMCEE..14..109S.doi:10.1186/1471-2148-14-109.PMC 4062890.PMID 24885141.
^Kefi, Rym; et al. (2016). "On the origin of Iberomaurusians: new data based on ancient mitochondrial DNA and phylogenetic analysis of Afalou and Taforalt populations".Mitochondrial DNA Part A.29 (1):147–157.doi:10.1080/24701394.2016.1258406.PMID 28034339.S2CID 4490910.
^Marom S, Friger M, Mishmar D (February 2017)."MtDNA meta-analysis reveals both phenotype specificity and allele heterogeneity: a model for differential association".Sci Rep.7 43449.doi:10.1038/srep43449.PMC 5322532.PMID 28230165.
^Martín-Jiménez R, Lurette O, Hebert-Chatelain E (August 2020). "Damage in Mitochondrial DNA Associated with Parkinson's Disease".DNA Cell Biol.39 (8):1421–1430.doi:10.1089/dna.2020.5398.PMID 32397749.
^Lowes H, Pyle A, Duddy M, Hudson G (May 2019)."Cell-free mitochondrial DNA in progressive multiple sclerosis".Mitochondrion.46:307–312.doi:10.1016/j.mito.2018.07.008.PMC 6509276.PMID 30098422.

External links

General
- Ian Logan'sMitochondrial DNA Site
- Mannis van Oven'sPhylotree

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