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Haloprogin

From Wikipedia, the free encyclopedia
Chemical compound
"Polik" redirects here. For other uses, seePolik (disambiguation).
Pharmaceutical compound
Haloprogin
Clinical data
Routes of
administration
Topical
ATC code
Legal status
Legal status
Identifiers
  • 1,2,4-Trichloro-5-[(3-iodoprop-2-yn-1-yl)oxy]benzene
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.011.169Edit this at Wikidata
Chemical and physical data
FormulaC9H4Cl3IO
Molar mass361.38 g·mol−1
3D model (JSmol)
Melting point113.5 °C (236.3 °F)
Solubility in waterInsoluble mg/mL (20 °C)
  • Clc1cc(OCC#CI)c(Cl)cc1Cl
  • InChI=1S/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2 checkY
  • Key:CTETYYAZBPJBHE-UHFFFAOYSA-N checkY
  (verify)

Haloprogin is anantifungal drug used to treatathlete's foot and otherfungalinfections.[1] It is marketed in creams under the trade namesHalotex,Mycanden,Mycilan, andPolik.

Action

[edit]

Haloprogin was previously used in 1% topical creams as an antifungal agent. It was marketedover-the-counter primarily to treattinea infections of theskin. The mechanism of action is unknown.[2]

Haloprogin had a high incidence of side effects including: irritation, burning, vesiculation (blisters), scaling, and itching. It has since been discontinued due to the emergence of more modern antifungals with fewer side effects.[3]

References

[edit]
  1. ^Rudolph RI (December 1979). "Haloprogin as treatment for fungal infections".Clinical and Experimental Dermatology.4 (4): 548.doi:10.1111/j.1365-2230.1979.tb01656.x.PMID 161212.S2CID 71471801.
  2. ^"Haloprogin".Drugs@FDA.Food and Drug Administration. Archived fromthe original on September 26, 2006. Retrieved2007-02-17.
  3. ^"Haloprogin".DrugBank. University of Alberta. Nov 6, 2006. Retrieved2007-02-17.
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Ergosterol
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