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HSPA14

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

For GroEL/60 kDa heat shock protein with the same symbol, seeGroEL.

HSPA14

Identifiers

Aliases

HSPA14, HSP70-4, HSP70L1, heat shock protein family A (Hsp70) member 14

External IDs

OMIM:610369;MGI:1354164;HomoloGene:74307;GeneCards:HSPA14;OMA:HSPA14 - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10p13	Start	14,838,306bp^[1]
Band	10p13	End	14,871,741bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 A1	Start	3,489,887bp^[2]
Band	2\|2 A1	End	3,513,851bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

middle temporal gyrus

right testis

rectum

deltoid muscle

left testis

gastrocnemius muscle

mucosa of sigmoid colon

vastus lateralis muscle

Skeletal muscle tissue of biceps brachii

Top expressed in

primitive streak

epiblast

otic placode

abdominal wall

otic vesicle

yolk sac

dermis

morula

morula

embryo

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding protein binding ATP binding ATPase activity heat shock protein binding protein folding chaperone activity unfolded protein binding misfolded protein binding
Cellular component	cytoplasm cytosol ribosome membrane polysome
Biological process	'de novo' cotranslational protein folding cytoplasmic translation regulation of translational fidelity response to unfolded protein cellular response to heat Unfolded Protein Response protein refolding chaperone cofactor-dependent protein refolding
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


51182


50497

Ensembl


ENSG00000187522


ENSMUSG00000109865

UniProt


Q0VDF9 Q8TAQ0


Q99M31

RefSeq (mRNA)


NM_001037538 NM_001278205 NM_016299


NM_001037542 NM_015765 NM_001355397

RefSeq (protein)


NP_057383 NP_001265134.1


NP_056580 NP_001342326

Location (UCSC)

Chr 10: 14.84 – 14.87 Mb

Chr 2: 3.49 – 3.51 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Heat shock 70 kDa protein 14 also known asHSP70-like protein 1 orheat shock protein HSP60 is aprotein that in humans is encoded by theHSPA14gene.^[5]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000187522 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000109865 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wan T, Zhou X, Chen G, An H, Chen T, Zhang W, Liu S, Jiang Y, Yang F, Wu Y, Cao X (March 2004)."Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant".Blood.103 (5):1747–54.doi:10.1182/blood-2003-08-2828.PMID 14592822.
^"Entrez Gene: HSPA14 heat shock 70kDa protein 14".

External links

[edit]

HSPA14+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

Posttranslational modification

Chaperones/
protein folding

Heat shock proteins/ Chaperonins	Hsp10/GroES Hsp27 Hsp47 HSP60/GroEL Hsp40/DnaJ A1 A2 A3 B1 B2 B11 B4 B6 B9 C1 C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α₁ α₂ β ER TRAP1
Other	Alpha crystallin Clusterin Survival of motor neuron SMN1 SMN2

Protein targeting

Ubiquitin
(ubiquitylation)

E1Ubiquitin-activating enzyme
- UBA1
- UBA2
- UBA3
- UBA5
- UBA6
- UBA7
- ATG7
- NAE1
- SAE1

E2Ubiquitin-conjugating enzyme
- A
- B
- C
- D1
- D2
- D3
- E1
- E2
- E3
- G1
- G2
- H
- I
- J1
- J2
- K
- L1
- L2
- L3
- L4
- L6
- M
- N
- O
- Q1
- Q2
- R1 (CDC34)
- R2
- S
- V1
- V2
- Z

E3Ubiquitin ligase
- VHL
- Cullin
- CBL
- MDM2
- FANCL
- UBR1

Ubiquitin-like proteins
(UBL)

SUMO protein (SUMOylation)	E1 SUMO-activating enzyme SAE1 SAE2 E2 SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4
Other	ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein

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