Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

HOXB2

From Wikipedia, the free encyclopedia

Protein-coding gene in humans
HOXB2
Identifiers
AliasesHOXB2, HOX2, HOX2H, Hox-2.8, K8, homeobox B2
External IDsOMIM:142967;MGI:96183;HomoloGene:37584;GeneCards:HOXB2;OMA:HOXB2 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for HOXB2
Genomic location for HOXB2
Band17q21.32Start48,540,894bp[1]
End48,545,109bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for HOXB2
Genomic location for HOXB2
Band11 D|11 59.85 cMStart96,241,351bp[2]
End96,244,838bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • seminal vesicula

  • right uterine tube

  • corpus epididymis

  • muscle layer of sigmoid colon

  • caput epididymis

  • left coronary artery

  • gastric mucosa

  • Descending thoracic aorta

  • right coronary artery

  • canal of the cervix
Top expressed in
  • embryo

  • somite

  • tail of embryo

  • transitional epithelium of urinary bladder

  • seminal vesicula

  • proximal tubule

  • adrenal gland

  • right kidney

  • enteric nervous system

  • medullary collecting duct
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3212

103889

Ensembl

ENSG00000173917

ENSMUSG00000075588

UniProt

P14652

P0C1T1

RefSeq (mRNA)

NM_002145

NM_134032

RefSeq (protein)

NP_002136

NP_598793

Location (UCSC)Chr 17: 48.54 – 48.55 MbChr 11: 96.24 – 96.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-B2 is aprotein that in humans is encoded by theHOXB2gene.[5][6][7]

Function

[edit]

This gene is a member of theAntp homeobox family and encodes anuclear protein with ahomeoboxDNA-binding domain. It is included in acluster of homeobox B genes located onchromosome 17. The encoded protein functions as asequence-specifictranscription factor that is involved in development. Increasedexpression of this gene is associated withpancreatic cancer.[7]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000173917Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000075588Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes".Genomics.7 (3): 460.doi:10.1016/0888-7543(90)90186-X.PMID 1973146.
  6. ^Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature".Cell.71 (4):551–3.doi:10.1016/0092-8674(92)90588-4.PMID 1358459.S2CID 13370372.
  7. ^ab"Entrez Gene: HOXB2 homeobox B2".

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.


(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous


Stub icon

This article on agene on humanchromosome 17 is astub. You can help Wikipedia byadding missing information.

Retrieved from "https://en.wikipedia.org/w/index.php?title=HOXB2&oldid=1301323049"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2026 Movatter.jp