HOT-x, also known as2,5-dimethoxy-4-(β-alkylthio)-N-hydroxyphenethylamines, are a group ofpsychedelic drugs of thephenethylamine and2C families.[1][2] They have ahydroxy group (HO) at theamine as well asmethoxy groups at the 2 and 5 positions and analkylthio (T) group at the 4 position of thephenyl ring.[1][2] The HOT-x drugs are theN-hydroxylanalogues of the corresponding2C-T-x drugs.[1][2] They weresynthesized and tested byAlexander Shulgin and reported in his 1991 bookPiHKAL (Phenethylamines I Have Known and Loved).[1][2]
The HOT-x drugs include the following:[1][2]
All three of the HOT-x drugs producepsychedelic effects according to Shulgin.[1][2] HOT-x drugs are said to be very similar to their 2C-T counterparts and might act asprodrugs to these compounds.[2]
| Phenethylamines |
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| Amphetamines |
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| Phentermines |
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| Cathinones | |||||||||||||||||
| Phenylisobutylamines (and further-extended) | |||||||||||||||||
| Catecholamines (and close relatives) |
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| Cyclized phenethylamines |
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| Related compounds |
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| Stimulants |
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| Depressants |
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| Hallucinogens |
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| Entactogens | |
| Psychiatric drugs |
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| Others |
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