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| Other names | 4-Ethylthio-2,5-dimethoxy-N-hydroxyphenethylamine; 2,5-Dimethoxy-4-ethylthio-N-hydroxyphenethylamine;N-Hydroxy-2C-T-2;N-OH-2C-T-2 |
| Routes of administration | Oral[1] |
| Drug class | Serotonergic psychedelic;Hallucinogen |
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| Pharmacokinetic data | |
| Metabolites | Possibly2C-T-2[1][2] |
| Onset of action | 30–40 minutes[1] Peak: 2 hours[1] |
| Duration of action | 6–10 hours[1] |
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| Chemical and physical data | |
| Formula | C12H19NO3S |
| Molar mass | 257.35 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 122 °C (252 °F) |
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HOT-2, also known as4-ethylthio-2,5-dimethoxy-N-hydroxyphenethylamine or asN-hydroxy-2C-T-2, is apsychedelic drug of thephenethylamine,2C, andHOT-x families.[1] It is theN-hydroxyderivative of2C-T-2.[1] The drug is takenorally.[1]
In his bookPiHKAL (Phenethylamines I Have Known and Loved),Alexander Shulgin lists HOT-2's dose range as 10 to 18 mgorally and itsduration as 6 to 10 hours.[1] The drug'sonset is 30 to 40 minutes and peak effects occur after 2 hours.[1] HOT-2's properties are very similar to those of2C-T-2, which has a dose of 12 to 25 mg orally, a duration of 6 to 8 hours, and an onset of less than 1 hour with a time to peak of 1 to 2 hours.[1][2] HOT-2 may act as aprodrug of 2C-T-2.[2]
The effects of HOT-2 have been reported to include somepsychedelic visuals like perceptual movement, flowing, and shimmering, increasedenergy,euphoria, uncomfortableness, easier or more difficult communication, somedifficulty concentrating andmental confusion, increasedheart rate andblood pressure, and nobody load.[1] Shulgin said of HOT-2 that it "seems to be a well tolerated, and generally pleasant material, with a mixture of sensory as well as insightful aspects. Something for everyone."[1]
Thechemical synthesis of HOT-2 has been described.[1]
Analogues of HOT-2 include2C-T-2,HOT-7 (N-hydroxy-2C-T-7), andHOT-17 (N-hydroxy-2C-T-17), among others.[1]
HOT-2 was first described in the literature byAlexander Shulgin in his 1991 bookPiHKAL (Phenethylamines I Have Known and Loved).[1]
This substance is a Class A drug in theDrugs controlled by the UK Misuse of Drugs Act.[3]
