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| Other names | 4-sec-Butylthio-2,5-dimethoxy-N-hydroxyphenethylamine; 2,5-Dimethoxy-4-sec-butylthio-N-hydroxyphenethylamine;N-Hydroxy-2C-T-17;N-OH-2C-T-17 |
| Routes of administration | Oral[1] |
| Drug class | Serotonergic psychedelic;Hallucinogen |
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| Pharmacokinetic data | |
| Metabolites | Possibly2C-T-17[1][2] |
| Onset of action | 0.5–1.5 hours[1] Peak: 3 hours[1] |
| Duration of action | 12–18 hours[1] |
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| Chemical and physical data | |
| Formula | C14H23NO3S |
| Molar mass | 285.40 g·mol−1 |
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HOT-17, also known as4-sec-butylthio-2,5-dimethoxy-N-hydroxyphenethylamine or asN-hydroxy-2C-T-17, is apsychedelic drug of thephenethylamine,2C, andHOT-x families.[1][3] It is theN-hydroxyderivative of2C-T-17.[1][3] The drug is takenorally.[1]
In his bookPiHKAL (Phenethylamines I Have Known and Loved),Alexander Shulgin lists HOT-17's dose range as 70 to 120 mgorally and itsduration as 12 to 18 hours.[1] The drug'sonset is 30 minutes to 1.5 hours and peak effects occur after 3 hours.[1] HOT-17's properties are very similar to those of2C-T-17, which has a dose of 60 to 100 mg orally, a duration of 10 to 15 hours, and an onset of 1 hour with a time to peak of 3 hours.[1][2] HOT-17 may act as aprodrug of 2C-T-17.[2]
The effects of HOT-17 have been reported to include "something going on upstairs", nosensory distortion, mildtime distortion, feeling light and slightly floaty, walking feeling pleasant due to the lightness, and nobody load, among others.[1] It was described as producing "plus-two" and "plus-three" experiences on theShulgin Rating Scale.[1] The compound is said to have an "unbelievably grim taste—not bitter, but simply evil".[1]
Thechemical synthesis of HOT-17 has been described.[1]
Analogues of HOT-17 include2C-T-17,HOT-2 (N-hydroxy-2C-T-2), andHOT-7 (N-hydroxy-2C-T-7), among others.[1][3]
HOT-17 was first described in the literature byAlexander Shulgin in his 1991 bookPiHKAL (Phenethylamines I Have Known and Loved).[1][3]
I first observed the intimate connection between an amine and a hydroxylamine with the discovery that N-hydroxy-MDA (MDOH) was equipotent and of virtually identical activity to the non-hydroxylated counterpart (MDA). And I have speculated in the recipe for MDOH about the possible biological interconversions of these kinds of compounds. And here, the simple addition of a hydroxyl group to the amine nitrogen atom of MDMA produces a new drug that is in most of its properties identical to MDMA. The concept has been extended to 2C-T-2, 2C-T-7, and 2C-T-17, where each of these three active compounds was structurally modified in exactly this way, by the addition of a hydroxyl group to the amine nitrogen atom. The results, HOT-2, HOT-7 and HOT-17 were themselves all active, and compared very closely with their non-hydroxylated prototypes.
