This gene encodes a member of theSWI/SNF family. Members of this family havehelicase andATPase activities and are thought to regulate transcription of certain genes by altering thechromatin structure around those genes. The encoded protein contains aRING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein.[6]
HLTF is a double-stranded DNA translocase, one of two human homologs ofSaccharomyces cerevisiaeRAD5 besidesSHPRH (SNF2 histone linker PHD RING helicase), that is able to carry outfork regression, similarly to Rad5.[7]
HLTF has been shown tointeract withUBE2N,[8]RAD18[8] andUBE2V2[8](see alsoSTRING functional and physical associations network : under the option 'search by name' enter 'protein name' of interest, HLTF, klick on 'GO! ', choose 'organism ', klick on 'continue ->').
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lin Y, Sheridan PL, Jones KA, Evans GA (Nov 1995). "The HIP116 SNF2/SW12-related transcription factor gene (SNF2L3) is located on human chromosome 3q25.1-q26.1".Genomics.27 (2):381–2.doi:10.1006/geno.1995.1064.PMID7558014.
^Unk I, Hajdú I, Blastyák A, Haracska L (Jan 2010). "Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance".DNA Repair (Amst).9 (3):257–67.doi:10.1016/j.dnarep.2009.12.013.PMID20096653.
Descheemaeker K (1993). "On the regulation of the plasminogen activator inhibitor-1 gene expression".Verh. K. Acad. Geneeskd. Belg.55 (3):225–64.PMID8342330.
Ding H, Descheemaeker K, Marynen P, et al. (1996). "Characterization of a helicase-like transcription factor involved in the expression of the human plasminogen activator inhibitor-1 gene".DNA Cell Biol.15 (6):429–42.doi:10.1089/dna.1996.15.429.PMID8672239.
Leung WK, Yu J, Bai AH, et al. (2003). "Inactivation of helicase-like transcription factor by promoter hypermethylation in human gastric cancer".Mol. Carcinog.37 (2):91–7.doi:10.1002/mc.10124.PMID12766908.S2CID46627646.
