Histone deacetylase 8 is anenzyme that in humans is encoded by theHDAC8gene.[5][6][7]
Histones play a critical role intranscriptional regulation,cell cycle progression, and developmental events. Histoneacetylation / deacetylation alterschromosome structure and affectstranscription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to apromoter.[7]
Histone deacetylase 8 is involved in skullmorphogenesis[8] and metabolic control of theERR-alpha /PGC1-alpha transcriptional complex.[9]
HDAC8 has been linked to number of disease states notably toacute myeloid leukemia and is related to actin cytoskeleton in smooth muscle cells.siRNA targeting HDAC8 showed anticancer effects.[10] Inhibition of HDAC8 induced apoptosis has been observed inT cell lymphomas.[11] In addition the HDAC8 enzyme has been implicated in the pathogenesis ofneuroblastoma.[12] Therefore, there has been interest in developing HDAC8 selective inhibitors.[13][14] At least 20 disease-causing mutations in this gene have been discovered.[15]
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
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