Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alterschromosome structure and affectstranscription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesseshistone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.[7]
HDAC5 is involved inmemory consolidation and suggests that development of more selectiveHDAC inhibitors for the treatment ofAlzheimer's disease should avoid targeting HDAC5.[9] Its function can be effectively examined by siRNA knockdown based on an independent validation.[10]
HDAC5 overexpression inurothelial carcinoma cell lines inhibits long-term proliferation but can promote epithelial-to-mesenchymal transition (EMT)[11]
^Watamoto K, Towatari M, Ozawa Y, Miyata Y, Okamoto M, Abe A, et al. (December 2003). "Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation".Oncogene.22 (57):9176–84.doi:10.1038/sj.onc.1206902.PMID14668799.S2CID24491249.
^Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR".Molecular Cell.9 (1):45–57.doi:10.1016/S1097-2765(01)00429-4.hdl:11858/00-001M-0000-002C-9FF9-9.PMID11804585.
^Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, et al. (November 2004). "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF".Oncogene.23 (54):8777–84.doi:10.1038/sj.onc.1208128.PMID15467736.S2CID26092755.
Mahlknecht U, Schnittger S, Ottmann OG, Schoch C, Mosebach M, Hiddemann W, Hoelzer D (October 2000). "Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5)".Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.1493 (3):342–8.doi:10.1016/S0167-4781(00)00191-3.PMID11018260.
Ozawa Y, Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, et al. (October 2001). "Histone deacetylase 3 associates with and represses the transcription factor GATA-2".Blood.98 (7):2116–23.doi:10.1182/blood.V98.7.2116.PMID11567998.
Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR".Molecular Cell.9 (1):45–57.doi:10.1016/S1097-2765(01)00429-4.hdl:11858/00-001M-0000-002C-9FF9-9.PMID11804585.
Huang Y, Tan M, Gosink M, Wang KK, Sun Y (May 2002). "Histone deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis".Cancer Research.62 (10):2913–22.PMID12019172.
