 E-Guggulsterone | |
 Z-Guggulsterone | |
| Names | |
|---|---|
| IUPAC name (8R,9S,10R,13S,14S)-17-Ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione | |
| Other names Pregna-4,17-diene-3,16-dione | |
| Identifiers | |
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3D model (JSmol) |
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| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.118.937 |
| UNII |
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| Properties | |
| C21H28O2 | |
| Molar mass | 312.453 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Guggulsterone is aphytosteroid found in theresin of theguggul plant,Commiphora mukul. Guggulsterone can exist as either of twostereoisomers,E-guggulsterone andZ-guggulsterone. In humans, it acts as anantagonist of thefarnesoid X receptor, which was once believed to result in decreasedcholesterol synthesis in theliver. Several studies have been published that indicate no overall reduction in total cholesterol occurs using various dosages of guggulsterone, and levels oflow-density lipoprotein ("bad cholesterol") increased in many people.[1][2] Nevertheless, guggulsterone is an ingredient in manynutritional supplements. Guggulsterone was also found to have interactions with the viral ADP ribose phosphatase enzyme ofSARS-CoV-2 and has been proposed as a potential candidate for the development of therapeutics for the treatment of COVID-19.[3]
Guggulsterone is a broad-spectrumligand ofsteroid hormone receptors, and is known to possess the following activities:[4][5][6][7]
Guggulsterone has been found inanimal research to be orally active; it has an absolutebioavailability of 42.9% afteroral administration in rats, with ahalf-life of around 10 hours in this species, indicating a goodpharmacokinetic profile.[8]
{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)