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Gubernaculum

From Wikipedia, the free encyclopedia
Embryonic structure
This article is about the structure in mammals. For the structure in roundworms, seeGubernaculum (parasitology). For the Latin word for rudder, seeGubernaculum (classical).
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Gubernaculum
Sagittal section through the pelvis of a newly born female child. (Label for round ligament of uterus visible at upper right.)
Details
Days60
PrecursorIntermediate mesoderm
Gives rise toGubernaculum testis (males),suspensory ligament of ovary,round ligament of uterus,ovarian ligament (females)
Identifiers
Latingubernaculum
MeSHD000071477
Anatomical terminology

The pairedgubernacula (from Ancient Greek κυβερνάω = pilot, steer), also called thecaudal genital ligament, are embryonic structures which begin as undifferentiatedmesenchyme attaching to thecaudal end of thegonads (testicles in males andovaries in females).

Structure

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The gubernaculum is present only during thedevelopment of the reproductive system. It is later replaced by distinct vestiges in males and females. The gubernaculum arises in the upper abdomen from the lower end of the gonadal ridge and helps guide the testis in its descent to the inguinal region.

Males

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  • The upper part of the gubernaculum degenerates.
  • The lower part persists as thegubernaculum testis ("scrotal ligament"). This ligament secures the testis to the most inferior portion of the scrotum, tethering it in place and limiting the degree to which the testis can move within the scrotum.
  • Cryptorchidism (undescended testes) are observed inINSL3-null male mice. This implicatesINSL3 as a key hormone in the growth and differentiation of the gubernaculum to allow transabdominal migration. Higher testicular temperatures associated with cryptorchidism is associated with reduced fertility.[1]

Females

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  • The gubernaculum has two vestigial remnants in females, theovarian ligament and theround ligament of the uterus (ligamentum teres uteri) which respectively serve to support the ovaries and uterus in the pelvis.
  • Development of the gubernaculum in female mice overexpressingINSL3 causes descended ovaries and reduced fertility. This ovarian descent is more pronounced by the additional administration of dihydrotestosterone, which suppresses development of the cranial suspensory ligament. Therefore, maintenance of the cranial suspensory ligament prevents abdominal translocation of the ovaries.[2]

Development

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As thescrotum andlabia majora form in males and females respectively, the gubernaculum aids in the descent of the gonads (both testes and ovaries).[3]

The testes descend to a greater degree than theovaries and ultimately pass through theinguinal canal into thescrotum.[3] The mechanism of this movement is still debated.[3]

History

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The gubernaculum was first described byJohn Hunter in 1762.[3] The term comes fromAncient Greek meaning to steer, pilot or therudder or helm.[3]

See also

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References

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  1. ^Nef and Parada, Nat Genet 1999, 22, 295-299
  2. ^Adham et al., Mol Endocrinol 2002, 16, 244-252
  3. ^abcdeBurgu, Berk; Baker, Linda A.; Docimo, Steven G. (2010-01-01), Gearhart, John P.; Rink, Richard C.; Mouriquand, Pierre D. E. (eds.),"CHAPTER 43 - CRYPTORCHIDISM",Pediatric Urology (Second Edition), Philadelphia: W.B. Saunders, pp. 563–576,ISBN 978-1-4160-3204-5, retrieved2021-02-03{{citation}}: CS1 maint: work parameter with ISBN (link)

External links

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  • Anatomy photo:36:06-0101 at the SUNY Downstate Medical Center - "Inguinal Region, Scrotum and Testes: The Scrotal Ligament"
Precursors
Internal
External
See also
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