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Guanoxan

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From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

Guanoxan
Clinical data

ATC code	C02CC03 (WHO)
Identifiers
IUPAC name 2-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)guanidine
CAS Number	2165-19-7^Y
PubChemCID	16564
ChemSpider	15704^N
UNII	9V0MRL0R5Y
CompTox Dashboard(EPA)	DTXSID3046166
Chemical and physical data
Formula	C₁₀H₁₃N₃O₂
Molar mass	207.233 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES c1ccc2c(c1)OCC(O2)CNC(=N)N
InChI InChI=1S/C10H13N3O2/c11-10(12)13-5-7-6-14-8-3-1-2-4-9(8)15-7/h1-4,7H,5-6H2,(H4,11,12,13)^N Key:HIUVKVDQFXDZHU-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Guanoxan is asympatholytic drug that was marketed asEnvacar by Pfizer in the UK to treathigh blood pressure. It was not widely used and was eventually withdrawn from the market due to liver toxicity.^[1]^[2]

References

[edit]

^Broadley KJ (1996).Autonomic Pharmacology. CRC Press. p. 276.ISBN 9780748405565.
^Wardell WM, Lasagna L (1975).Regulation and drug development. Washington: American Enterprise Institute for Public Policy Research. p. 65.ISBN 9780844731674.

Sympatholytic (and closely related)antihypertensives (C02)

Sympatholytics
(antagonizeα-adrenergic
vasoconstriction)

Central

α₂-Adrenergic receptor agonists	Clonidine Guanabenz Guanfacine Guanoxabenz Methyldopa^# Tiamenidine^‡
Adrenergic release inhibitors	Bethanidine Bretylium Debrisoquine Guanadrel Guanazodine Guancydine Guanethidine Guanoclor Guanoxan
Imidazoline receptor agonists	Moxonidine Rilmenidine Tolonidine
Ganglion-blocking/nicotinic antagonists	Hexamethonium^‡ Mecamylamine Pentolinium Trimethaphan

Peripheral

Indirect

Monoamine oxidase inhibitors	Pargyline^‡
VMAT inhibitors	Bietaserpine Deserpidine Methoserpidine Reserpine Syrosingopine
Tyrosine hydroxylase inhibitors	Metirosine

Direct

α₁-Adrenergic receptor blockers	Doxazosin Ketanserin Indoramin Prazosin Trimazosin Urapidil
Non-selective α-adrenergic receptor blockers	Phentolamine

Otherantagonists

Serotonin receptor antagonists	Ketanserin Lidanserin
Endothelin receptor antagonists (for PHTooltip Pulmonary hypertension)	dual (Aprocitentan,Bosentan,Macitentan (+tadalafil),Riociguat) selective (Ambrisentan (+tadalafil),Sitaxentan,Sotatercept)

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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