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| Names | |
|---|---|
| IUPAC name 2-(1,4-Dioxaspiro[4.5]decan-2-ylmethyl)guanidine | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider |
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| KEGG |
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| MeSH | C004945 |
| UNII | |
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| Properties | |
| C10H19N3O2 | |
| Molar mass | 213.281 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Guanadrel is anantihypertensive agent.[1] It is used in the form of itssulfate.
Guanadrel is a postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via thenorepinephrine pump; guanadrel slowly displaces norepinephrine from its storage in nerve endings and thereby blocks the release of norepinephrine normally produced by nerve stimulation. The reduction in neurotransmitter release in response tosympathetic nerve stimulation, as a result ofcatecholamine depletion, leads to reduced arteriolarvasoconstriction, especially the reflex increase in sympathetic tone that occurs with a change in position. Guanadrel is rapidly and well absorbed from gastrointestinal tract.[2]
In 1981 theJAMA reported guanadrel as an effective step II or step III treatment of hypertension.[3]
