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Guacetisal

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Chemical compound

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Pharmaceutical compound
Guacetisal
Clinical data
Trade namesBroncaspin; Balsacetil; Guaiaspir; Prontomucil
Other namesAspirin guaiacol ester;O-Methoxyphenyl salicylate acetate
ATC code
Identifiers
  • 2-Methoxyphenyl 2-acetoxybenzoate
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.054.221Edit this at Wikidata
Chemical and physical data
FormulaC16H14O5
Molar mass286.283 g·mol−1
3D model (JSmol)
Melting point72 to 74.5 °C (161.6 to 166.1 °F)
  • O=C(Oc1ccccc1C(=O)Oc2ccccc2OC)C
  • InChI=1S/C16H14O5/c1-11(17)20-13-8-4-3-7-12(13)16(18)21-15-10-6-5-9-14(15)19-2/h3-10H,1-2H3
  • Key:HSJFYRYGGKLQBT-UHFFFAOYSA-N

Guacetisal is a drug that has been used to treatinflammatory respiratory diseases.[1] Chemically, it is anester resulting from the combination ofaspirin andguaiacol.[citation needed]

References

[edit]
  1. ^Vizioli A, Zamperini D, Ursaia G (December 1982). "[Clinical trial of guacetisal in aged subjects with inflammatory diseases of the respiratory tract]".La Clinica Terapeutica.103 (5):527–33.PMID 6761043.
pyrazolones /
pyrazolidines
salicylates
acetic acid derivatives
and related substances
oxicams
propionic acid
derivatives (profens)
n-arylanthranilic
acids (fenamates)
COX-2 inhibitors
(coxibs)
other
NSAID
combinations
Key:underline indicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;withdrawn drugs;veterinary use.
Receptor
(ligands)
DP (D2)Tooltip Prostaglandin D2 receptor
DP1Tooltip Prostaglandin D2 receptor 1
DP2Tooltip Prostaglandin D2 receptor 2
EP (E2)Tooltip Prostaglandin E2 receptor
EP1Tooltip Prostaglandin EP1 receptor
EP2Tooltip Prostaglandin EP2 receptor
EP3Tooltip Prostaglandin EP3 receptor
EP4Tooltip Prostaglandin EP4 receptor
Unsorted
FP (F)Tooltip Prostaglandin F receptor
IP (I2)Tooltip Prostacyclin receptor
TP (TXA2)Tooltip Thromboxane receptor
Unsorted
Enzyme
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COX
(
PTGS)
PGD2STooltip Prostaglandin D synthase
PGESTooltip Prostaglandin E synthase
PGFSTooltip Prostaglandin F synthase
PGI2STooltip Prostacyclin synthase
TXASTooltip Thromboxane A synthase
Others
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