Golidocitinib

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Pharmaceutical compound

Golidocitinib
Clinical data

Trade names	高瑞哲 (Gao Ruizhe)
Other names	AZD-4205, AZD4205, JAK1-IN-3
Legal status
Legal status	Rx in China
Identifiers
IUPAC name (2R)-N-(3-{2-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-1H-indol-7-yl)-2-(4-methylpiperazin-1-yl)propanamide
CAS Number	2091134-68-6
PubChemCID	126715380
DrugBank	DB18057
ChemSpider	71117616
UNII	3BY9Z3M34G
KEGG	D12502
ChEMBL	ChEMBL4577523
Chemical and physical data
Formula	C₂₅H₃₁N₉O₂
Molar mass	489.584 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COc1nn(C)cc1Nc1nccc(-c2c[nH]c3c(NC(=O)[C@@H](C)N4CCN(C)CC4)cccc23)n1
InChI InChI=InChI=1S/C25H31N9O2/c1-16(34-12-10-32(2)11-13-34)23(35)28-20-7-5-6-17-18(14-27-22(17)20)19-8-9-26-25(29-19)30-21-15-33(3)31-24(21)36-4/h5-9,14-16,27H,10-13H2,1-4H3,(H,28,35)(H,26,29,30)/t16-/m1/s1 Key:CVCVOSPZEVINRM-MRXNPFEDSA-N

Golidocitinib is a pharmaceutical drug for the treatment of cancer. In June 2024, it was given conditional approval in China for the treatment of relapsed or refractoryperipheral T-cell lymphoma.^[1]

Golidocitinib is classified as aJanus kinase inhibitor.^[2]^[3]

References

[edit]

^Keam SJ (October 2024). "Golidocitinib: First Approval".Drugs.84 (10):1319–1324.doi:10.1007/s40265-024-02089-2.PMID 39298087.
^Song Y, Malpica L, Cai Q, Zhao W, Zhou K, Wu J, et al. (January 2024). "Golidocitinib, a selective JAK1 tyrosine-kinase inhibitor, in patients with refractory or relapsed peripheral T-cell lymphoma (JACKPOT8 Part B): a single-arm, multinational, phase 2 study".The Lancet. Oncology.25 (1):117–125.doi:10.1016/S1470-2045(23)00589-2.PMID 38092009.
^Jin J, Zhang L, Zou L, Li Z, Wu H, Zhou K, et al. (2024). "Maintenance Therapy of Golidocitinib, a JAK1 Selective Inhibitor, in Patients with Peripheral T Cell Lymphomas after First-Line Systemic Therapy: Updates of the Phase 2 Study (JACKPOT26)".Blood.144: 6368.doi:10.1182/blood-2024-211891.

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