| Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.2.1.114 | ||||||||
| CAS no. | 82047-77-6 | ||||||||
| Alt. names | mannosidase II, exo-1,3-1,6-α-mannosidase, α-D-mannosidase II, α-mannosidase II, α-3,6-mannosidase, GlcNAc transferase I-dependent α1,3[α1,6]mannosidase, Golgi α-mannosidase II, ManII, 1,3(1,6)-α-D-mannosidase, 1,3-(1,6-)mannosyl-oligosaccharide α-D-mannohydrolase | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDBPDBePDBsum | ||||||||
| |||||||||
Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase, also known asGolgi α-mannosidase II, is anenzyme withsystematic name(1→3)-(1→6)-mannosyl-oligosaccharide α-D-mannohydrolase.[1][2][3][4] Itcatalyses thehydrolysis of the terminal (1→3)- and (1→6)-linked α-D-mannose residues in the mannosyl-oligosaccharide Man5(GlcNAc)3.
This enzyme is involved in the synthesis ofglycoproteins. It is a key enzyme ofN-linked glycan processing and is inhibited by small moleculeswainsonine.[5]
