Glia maturation factor is aneurotrophic factor implicated in nervous system development, angiogenesis and immune function. In humans, theglia maturation factor beta andglia maturation factor gammaproteins are encoded by theGMFB andGMFGgenes, respectively.[1]
The structures of mouse glia maturation factors beta and gamma, solved by both crystallography and NMR, reveal similarities and critical differences withADF-H (actin depolymerization factor homology) domains and suggest new means of experimentally addressing the function of this protein family.[2]
Stereoribbon diagram of the crystal structure of GMFG. Spectral coloring is from blue (N-terminus) to red (C-terminus). Secondary structural elements are indicated
