Swiss-Dutch molecular biologist
Françoise Gisou van der Goot (born 19 September 1964 inTehran )[ 2] cell biologist .[ 1] [ 3] EPFL (École Polytechnique Fédérale de Lausanne) .[ 4]
Gisou van der Goot studiedengineering at theÉcole Centrale de Paris . She pursued aPhD inmolecular biophysics at theSaclay Nuclear Research Centre (Pierre and Marie Curie University ).[ 5] postdoctoral researcher at theEuropean Molecular Biology Laboratory (EMBL) inHeidelberg . In 1994 she worked as a group leader in the Department of Biochemistry of theUniversity of Geneva and, subsequently, from 2001 asassociate professor in the department ofmicrobiology andmolecular medicine . Since 2006, she has been full professor ofmolecular andcellular microbiology at the School of Life Sciences ofEPFL ,[ 6] [ 7] [ 8] EPFL for a term starting in 2021.[ 4]
Gisou van der Goot leads the Laboratory of Cell and Membrane Biology at theSchool of Life Sciences of theÉcole Polytechnique Fédérale de Lausanne (EPFL).[ 9] cellular and intracellular membrane dynamics. Notably, it aims to better understand the way proteinpalmitoylation regulatesendoplasmic reticulum function andprotein trafficking ,[ 10] anthrax toxin to penetrate target cells,[ 11] juvenile hyaline fibromatosis , a rare and debilitatinggenetic disorder .[ 12] COVID-19 pandemic , Gisou van der Goot declared to have dedicated part of her laboratory to studySARS-CoV-2 .[ 13]
Gisou van der Goot obtained aEuropean Molecular Biology Organization (EMBO) Young Investigator award[ 14] Howard Hughes International Scholar award in 2005. In 2009, she received the Leenaards Foundation Research Prize[ 15] Marcel Benoist Prize .[ 16] biochemistry of thebacterial toxin of theanthrax pathogen at the hostcell membrane . In 2020, she was awarded theSuffrage Science award .[ 17]
She has been member of scientific boards such as theSwiss National Science Foundation ,[ 18] Swiss Science Council and theEuropean Research Council (ERC).[ 6]
Klionsky, Daniel J.; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Acevedo Arozena, Abraham; Adachi, Hiroaki; Adams, Christopher M.; Adams, Peter D.; Adeli, Khosrow; Adhihetty, Peter J.; Adler, Sharon G.; Agam, Galila; Agarwal, Rajesh; Aghi, Manish K.; Agnello, Maria; Agostinis, Patrizia; Aguilar, Patricia V.; Aguirre-Ghiso, Julio; Airoldi, Edoardo M.; Ait-Si-Ali, Slimane; Akematsu, Takahiko; Akporiaye, Emmanuel T.; Al-Rubeai, Mohamed; Albaiceta, Guillermo M.; Albanese, Chris; Albani, Diego; Albert, Matthew L.; Aldudo, Jesus; et al. (2016)."Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)" .Autophagy .12 (1):1– 222.doi :10.1080/15548627.2015.1100356 .PMC 4835977 PMID 26799652 . Abrami, Laurence; Liu, Shihui; Cosson, Pierre; Leppla, Stephen H.; Van Der Goot, F. Gisou (2003)."Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process" .Journal of Cell Biology .160 (3):321– 328.doi :10.1083/jcb.200211018 .PMC 2172673 PMID 12551953 . Gurcel, Laure; Abrami, Laurence; Girardin, Stephen; Tschopp, Jurg; Van Der Goot, F. Gisou (2006)."Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival" .Cell .126 (6):1135– 1145.doi :10.1016/j.cell.2006.07.033 PMID 16990137 .S2CID 616037 . Pizarro-Cerdá, Javier; MéResse, StéPhane; Parton, Robert G.; Van Der Goot, Gisou; Sola-Landa, Alberto; Lopez-Goñi, Ignacio; Moreno, Edgardo; Gorvel, Jean-Pierre (1998)."Brucella abortus Transits through the Autophagic Pathway and Replicates in the Endoplasmic Reticulum of Nonprofessional Phagocytes" .Infection and Immunity .66 (12):5711– 5724.doi :10.1128/IAI.66.12.5711-5724.1998 .PMC 108722 PMID 9826346 . Van Der Goot, F. G.; González-Mañas, J. M.; Lakey, J. H.; Pattus, F. (1991). "A 'molten-globule' membrane-insertion intermediate of the pore-forming domain of colicin A".Nature .354 (6352):408– 410.Bibcode :1991Natur.354..408V .doi :10.1038/354408a0 .PMID 1956406 .S2CID 4301346 . Gruenberg, Jean; Van Der Goot, F. Gisou (2006). "Mechanisms of pathogen entry through the endosomal compartments".Nature Reviews Molecular Cell Biology .7 (7):495– 504.doi :10.1038/nrm1959 .PMID 16773132 .S2CID 429568 . Peraro, Matteo Dal; Van Der Goot, F. Gisou (2016). "Pore-forming toxins: Ancient, but never really out of fashion".Nature Reviews Microbiology .14 (2):77– 92.doi :10.1038/nrmicro.2015.3 .PMID 26639780 .S2CID 6784199 . Dupont, Nicolas; Lacas-Gervais, Sandra; Bertout, Julie; Paz, Irit; Freche, Barbara; Van Nhieu, Guy Tran; Van Der Goot, F. Gisou; Sansonetti, Philippe J.; Lafont, Frank (2009)."Shigella Phagocytic Vacuolar Membrane Remnants Participate in the Cellular Response to Pathogen Invasion and Are Regulated by Autophagy" .Cell Host & Microbe .6 (2):137– 149.doi :10.1016/j.chom.2009.07.005 PMID 19683680 . Gisou van der Goot is married to Swiss biologistJean Gruenberg and has two children.[citation needed
^a b Gisou van der Goot publications indexed byGoogle Scholar ^ "Françoise Gisou van der Goot reçoit le Prix Marcel Benoist 2009" .admin.ch . Retrieved2020-08-01 .^ Gisou van der Goot publications fromEurope PubMed Central ^a b "Board appoints new members of the Executive Boards of ETH Zurich and EPFL | ETH-Board" .ethrat.ch . Archived fromthe original on 2021-04-20. Retrieved2020-09-25 .^ ORCID."Gisou van der Goot (0000-0002-8522-274X)" .orcid.org . Retrieved2021-01-20 . ^a b "Gisou van der Goot" .people.epfl.ch . Retrieved2020-07-29 .^ "Van der Goot Lab - EPFL" . Retrieved2020-07-29 .^ Evangelista, Sandy (2020-04-06)." . {{cite journal }}:Cite journal requires|journal= (help ) ^ "van der Goot Lab – Laboratory of Cell and Membrane Biology" .epfl.ch . Retrieved2020-08-13 .^ Blaskovic, Sanja; Blanc, Mathieu; Goot, F. Gisou van der (2013)."What does S-palmitoylation do to membrane proteins?" .The FEBS Journal .280 (12):2766– 2774.doi :10.1111/febs.12263 ISSN 1742-4658 .PMID 23551889 . ^ Abrami, Laurence; Liu, Shihui; Cosson, Pierre; Leppla, Stephen H.; van der Goot, F. Gisou (2003)."Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process" .Journal of Cell Biology .160 (3):321– 328.doi :10.1083/jcb.200211018 ISSN 0021-9525 .PMC 2172673 PMID 12551953 . ^ Deuquet, Julie; Lausch, Ekkehart; Guex, Nicolas; Abrami, Laurence; Salvi, Suzanne; Lakkaraju, Asvin; Ramirez, Maria Celeste M.; Martignetti, John A.; Rokicki, Dariusz; Bonafe, Luisa; Superti-Furga, Andrea (2011)."Hyaline Fibromatosis Syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors" .EMBO Molecular Medicine .3 (4):208– 221.doi :10.1002/emmm.201100124 .ISSN 1757-4676 .PMC 3377065 PMID 21328543 . ^ "Gisou van der Goot, de l'anthrax au Covid-19" .Le Temps (in French). 2020-07-02.ISSN 1423-3967 . Retrieved2020-08-13 .^ "Find an EMBO Young Investigator / EMBO Installation Grantee / EMBO Global Investigator" .yip-search.embo.org . Retrieved2020-07-29 .^ "Etude des mécanismes amenant des pathogènes à être mortels pour l'homme" .Fondation Leenaards - Favoriser la dynamique créatrice (in French). Retrieved2020-07-29 .^ "Past laureates – Marcel Benoist Foundation" .marcel-benoist.ch . Retrieved2020-08-01 .^ Arthur, Sophie (2020-10-22)."Life Sciences Awardee 2020: Professor Gisou van der Goot" .suffragescience . Retrieved2020-10-23 . [dead link ^ "Former SSC members" .swir.ch . Retrieved2020-07-29 .
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