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| Routes of administration | By mouth (tablet) |
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| Formula | C12H13N3 |
| Molar mass | 199.257 g·mol−1 |
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Gapicomine (INN) is acoronaryvasodilator. It has been withdrawn from the market in the countries it was used in.[1]
Also, gapicomine is a major component in the drugBicordin.[2]
Gapicomine was discovered in 1970 byPolishchemistStanisław Biniecki. It was first published about in an article ofThe Polish Journal of Medicine and Pharmacy describing the derivative drugBicordin in 1974.[3]
The oxime formation between isonicotinaldehyde [872-85-5] (1) and hydroxylamine gives 4-Pyridinealdoxime [696-54-8] (2). This is then reduced by catalytic hydrogenation over Raney-Nickel into 4-Picolylamine [3731-53-1] (3). Reductive amination of the last with a second equivalent of isonicotinaldehyde affords gapicomine (4).
