Antiviral drug
Pharmaceutical compound
Galidesivir Legal status Legal status Identifiers (2S ,3S ,4R ,5R )-2-(4-Amino-5H -pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol
CAS Number PubChem CID ChemSpider UNII Chemical and physical data Formula C 11 H 15 N 5 O 3 Molar mass −1 3D model (JSmol ) InChI=1S/C11H15N5O3/c12-11-8-6(14-3-15-11)4(1-13-8)7-10(19)9(18)5(2-17)16-7/h1,3,5,7,9-10,13,16-19H,2H2,(H2,12,14,15)/t5-,7+,9-,10+/m1/s1
Key:AMFDITJFBUXZQN-KUBHLMPHSA-N
Galidesivir (BCX4430 ,immucillin-A ) is anantiviral drug , anadenosine analog [ 1] nucleoside analog ).[ 2] BioCryst Pharmaceuticals with funding fromNIAID , originally intended as a treatment forhepatitis C , but subsequently developed as a potential treatment for deadlyfilovirus infections such asEbola virus disease andMarburg virus disease , as well asZika virus .[ 3] phase 1 human trial in Brazil forcoronavirus .[ 4]
It also showsbroad-spectrum antiviral effectiveness against a range of other RNA virus families, includingbunyaviruses ,arenaviruses ,paramyxoviruses ,coronaviruses ,flaviviruses , andphleboviruses .[ 5] [ 1] Ebola virus epidemic in West Africa .[ 6]
Galidesivir later showed efficacy againstZika virus in a mouse model.[ 7]
Galidesivir abrogates viremia in Zika virus–infected rhesus Macaques.[ 8]
Galidesivir is one of several antiviral drugs being tested forcoronavirus disease 2019 .[ 9]
On April 9, 2020, BioCryst opened enrollment into a randomized, double-blind,placebo -controlled clinical trial to assess the safety, clinical impact and antiviral effects of galidesivir in patients withCOVID-19 .[ 4]
^a b Warren TK, Wells J, Panchal RG, Stuthman KS, Garza NL, Van Tongeren SA, et al. (April 2014)."Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430" .Nature .508 (7496):402– 405.Bibcode :2014Natur.508..402W .doi :10.1038/nature13027 .PMC 7095208 PMID 24590073 . ^ Kamat SS, Burgos ES, Raushel FM (October 2013)."Potent inhibition of the C-P lyase nucleosidase PhnI by Immucillin-A triphosphate" .Biochemistry .52 (42):7366– 7368.doi :10.1021/bi4013287 .PMC 3838859 PMID 24111876 . ^ BioCryst Pharmaceuticals, Inc. (June 10, 2020)."Galidesivir Stops Zika Viral Replication in Primate Model" .GlobeNewswire News Room (Press release). ^a b Clinical trial numberNCT03891420 ClinicalTrials.gov ^ Westover JB, Mathis A, Taylor R, Wandersee L, Bailey KW, Sefing EJ, et al. (August 2018)."Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters" .Antiviral Research .156 :38– 45.doi :10.1016/j.antiviral.2018.05.013 .PMC 6035881 PMID 29864447 . ^ Rodgers P (8 April 2014)."BioWar Lab Helping To Develop Treatment For Ebola" .Forbes Magazine . ^ Julander JG, Siddharthan V, Evans J, Taylor R, Tolbert K, Apuli C, et al. (January 2017)."Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model" .Antiviral Research .137 :14– 22.doi :10.1016/j.antiviral.2016.11.003 .PMC 5215849 PMID 27838352 . ^ Lim SY, Osuna CE, Best K, Taylor R, Chen E, Yoon G, et al. (June 2020)."A direct-acting antiviral drug abrogates viremia in Zika virus-infected rhesus macaques" .Science Translational Medicine .12 (547) eaau9135.doi :10.1126/scitranslmed.aau9135 .PMC 7370316 PMID 32522808 . ^ Duddu P (19 February 2020)."Coronavirus outbreak: Vaccines/drugs in the pipeline for Covid-19" .clinicaltrialsarena.com . Archived fromthe original on 19 February 2020. Retrieved19 February 2020 .
