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Gadoteridol

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Gadoteridol
Clinical data
Other names(10-(2-(hydroxy-κO)propyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3)-κN1,κN4,κN7,κN10,κO1,κO4,κO7)-gadolinium
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration
IV
ATC code
Legal status
Legal status
Identifiers
  • gadolinium(+3) cation; 2-[4-(2-hydroxypropyl)-7,10-bis(2-oxido-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC17H29GdN4O7
Molar mass558.69 g·mol−1
3D model (JSmol)
  • [Gd+3].[O-]C(=O)CN1CCN(CCN(CCN(CC(O)C)CC1)CC([O-])=O)CC([O-])=O
  • InChI=1S/C17H32N4O7.Gd/c1-14(22)10-18-2-4-19(11-15(23)24)6-8-21(13-17(27)28)9-7-20(5-3-18)12-16(25)26;/h14,22H,2-13H2,1H3,(H,23,24)(H,25,26)(H,27,28);/q;+3/p-3 checkY
  • Key:DPNNNPAKRZOSMO-UHFFFAOYSA-K checkY
 ☒NcheckY (what is this?)  (verify)

Gadoteridol (INN) is agadolinium-based MRI contrast agent, used particularly in the imaging of thecentral nervous system. It is sold under the brand nameProHance.[3] Gadoteridol was first approved for use in the United States in 1992.[4]

References

[edit]
  1. ^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)".nctr-crs.fda.gov.FDA. Retrieved22 Oct 2023.
  2. ^"Prohance Product information".Health Canada. 30 July 1998. Retrieved19 April 2024.
  3. ^Bracco Diagnostic Inc. (26 October 2022)."Gadoteridol (ProHance) prescribing information".DailyMed. U.S.National Library of Medicine. Retrieved17 May 2023.
  4. ^Morgan DE, Spann JS, Lockhart ME, Winningham B, Bolus DN (April 2011). "Assessment of adverse reaction rates during gadoteridol-enhanced MR imaging in 28,078 patients".Radiology.259 (1):109–16.doi:10.1148/radiol.10100906.PMID 21248237.Specifically, the rate of nausea (0.530%) was less than half the rate (1.4%) in clinical trials of 1251 patients, leading to FDA approval in 1992.
X-ray and CT
Iodinated,
Water soluble
Nephrotropic,
high osmolar
Nephrotropic,
low osmolar
Hepatotropic
Iodinated,
Water insoluble
Non-iodinated
MRI
Paramagnetic
Superparamagnetic
Other
Ultrasound


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