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GTF2F1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
GTF2F1
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1F3U,1I27,1J2X,1NHA,1ONV,2K7L,5IY9,5IYA,5IYC,5IYB,5IY7,5IY8,5IYD,5IY6

Identifiers
AliasesGTF2F1, general transcription factor IIF, polypeptide 1, 74kDa, BTF4, RAP74, TF2F1, TFIIF, general transcription factor IIF subunit 1
External IDsOMIM:189968;MGI:1923848;HomoloGene:1585;GeneCards:GTF2F1;OMA:GTF2F1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for GTF2F1
Genomic location for GTF2F1
Band19p13.3Start6,379,572bp[1]
End6,393,981bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for GTF2F1
Genomic location for GTF2F1
Band17|17 DStart57,310,405bp[2]
End57,318,288bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellum

  • cerebellar cortex

  • cerebellar hemisphere

  • left testis

  • right hemisphere of cerebellum

  • right testis

  • left ovary

  • prefrontal cortex

  • anterior pituitary

  • superior frontal gyrus
Top expressed in
  • saccule

  • otic placode

  • otic vesicle

  • seminiferous tubule

  • neural layer of retina

  • tail of embryo

  • primitive streak

  • primary oocyte

  • yolk sac

  • genital tubercle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2962

98053

Ensembl

ENSG00000125651

ENSMUSG00000002658

UniProt

P35269

Q3THK3

RefSeq (mRNA)

NM_002096

NM_133801

RefSeq (protein)

NP_002087

NP_598562

Location (UCSC)Chr 19: 6.38 – 6.39 MbChr 17: 57.31 – 57.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

General transcription factor IIF subunit 1 is aprotein that in humans is encoded by theGTF2F1gene.[5][6]

Interactions

[edit]

GTF2F1 has been shown tointeract with:

See also

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References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000125651Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000002658Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (March 1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II".Nature.355 (6359):464–7.Bibcode:1992Natur.355..464F.doi:10.1038/355464a0.PMID 1734284.S2CID 1241044.
  6. ^"Entrez Gene: GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa".
  7. ^Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (October 1998)."FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO".J. Biol. Chem.273 (42):27593–601.doi:10.1074/jbc.273.42.27593.PMID 9765293.
  8. ^abcdefScully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997)."BRCA1 is a component of the RNA polymerase II holoenzyme".Proc. Natl. Acad. Sci. U.S.A.94 (11):5605–10.Bibcode:1997PNAS...94.5605S.doi:10.1073/pnas.94.11.5605.PMC 20825.PMID 9159119.
  9. ^Kim MK, Nikodem VM (October 1999)."hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation".Mol. Cell. Biol.19 (10):6833–44.doi:10.1128/MCB.19.10.6833.PMC 84680.PMID 10490622.
  10. ^Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997)."CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription".Mol. Cell. Biol.17 (10):6029–39.doi:10.1128/MCB.17.10.6029.PMC 232452.PMID 9315662.
  11. ^Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D (September 1998)."A human RNA polymerase II complex containing factors that modify chromatin structure".Mol. Cell. Biol.18 (9):5355–63.doi:10.1128/MCB.18.9.5355.PMC 109120.PMID 9710619.
  12. ^Joliot V, Demma M, Prywes R (February 1995). "Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor".Nature.373 (6515):632–5.Bibcode:1995Natur.373..632J.doi:10.1038/373632a0.PMID 7854423.S2CID 47196160.
  13. ^Zhu H, Joliot V, Prywes R (February 1994)."Role of transcription factor TFIIF in serum response factor-activated transcription".J. Biol. Chem.269 (5):3489–97.doi:10.1016/S0021-9258(17)41889-8.PMID 8106390.
  14. ^Dikstein R, Ruppert S, Tjian R (March 1996)."TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74".Cell.84 (5):781–90.doi:10.1016/s0092-8674(00)81055-7.PMID 8625415.S2CID 18490534.
  15. ^abRuppert S, Tjian R (November 1995)."Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation".Genes Dev.9 (22):2747–55.doi:10.1101/gad.9.22.2747.PMID 7590250.
  16. ^Siegert JL, Robbins PD (January 1999)."Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250".Mol. Cell. Biol.19 (1):846–54.doi:10.1128/MCB.19.1.846.PMC 83941.PMID 9858607.
  17. ^abMalik S, Guermah M, Roeder RG (March 1998)."A dynamic model for PC4 coactivator function in RNA polymerase II transcription".Proc. Natl. Acad. Sci. U.S.A.95 (5):2192–7.Bibcode:1998PNAS...95.2192M.doi:10.1073/pnas.95.5.2192.PMC 19292.PMID 9482861.
  18. ^Fang SM, Burton ZF (May 1996)."RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding".J. Biol. Chem.271 (20):11703–9.doi:10.1074/jbc.271.20.11703.PMID 8662660.

Further reading

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External links

[edit]
PDB gallery
  • 1f3u: CRYSTAL STRUCTURE OF THE RAP30/74 INTERACTION DOMAINS OF HUMAN TFIIF
    1f3u: CRYSTAL STRUCTURE OF THE RAP30/74 INTERACTION DOMAINS OF HUMAN TFIIF
  • 1i27: CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)
    1i27: CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)
  • 1j2x: Crystal structure of RAP74 C-terminal domain complexed with FCP1 C-terminal peptide
    1j2x: Crystal structure of RAP74 C-terminal domain complexed with FCP1 C-terminal peptide
  • 1nha: Solution Structure of the Carboxyl-Terminal Domain of RAP74 and NMR Characterization of the FCP-Binding Sites of RAP74 and CTD of RAP74, the subunit of Human TFIIF
    1nha: Solution Structure of the Carboxyl-Terminal Domain of RAP74 and NMR Characterization of the FCP-Binding Sites of RAP74 and CTD of RAP74, the subunit of Human TFIIF
  • 1onv: NMR Structure of a Complex Containing the TFIIF Subunit RAP74 and the RNAP II CTD Phosphatase FCP1
    1onv: NMR Structure of a Complex Containing the TFIIF Subunit RAP74 and the RNAP II CTD Phosphatase FCP1
(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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