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GRIN3B

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GRIN3B

Identifiers

Aliases

GRIN3B, GluN3B, NR3B, glutamate ionotropic receptor NMDA type subunit 3B

External IDs

OMIM:606651;MGI:2150393;HomoloGene:15606;GeneCards:GRIN3B;OMA:GRIN3B - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.3	Start	1,000,419bp^[1]
Band	19p13.3	End	1,009,732bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 C1	Start	79,806,549bp^[2]
Band	10\|10 C1	End	79,813,024bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right uterine tube

olfactory zone of nasal mucosa

testicle

bronchial epithelial cell

stromal cell of endometrium

right lung

canal of the cervix

granulocyte

left lobe of thyroid gland

right hemisphere of cerebellum

Top expressed in

lumbar subsegment of spinal cord

motor neuron

facial motor nucleus

spermatid

seminiferous tubule

ascending aorta

aortic valve

anterior horn of spinal cord

morula

embryo

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	calcium channel activity glycine binding ion channel activity ionotropic glutamate receptor activity cation channel activity neurotransmitter binding neurotransmitter receptor activity extracellularly glutamate-gated ion channel activity signaling receptor activity
Cellular component	integral component of membrane postsynaptic membrane membrane plasma membrane synapse cell junction soma NMDA selective glutamate receptor complex postsynapse
Biological process	regulation of calcium ion transport ion transport ionotropic glutamate receptor signaling pathway protein insertion into membrane calcium ion transmembrane transport cation transmembrane transport ion transmembrane transport excitatory postsynaptic potential signal transduction
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


116444


170483

Ensembl


ENSG00000116032


ENSMUSG00000035745

UniProt


O60391 Q5F0I5


Q91ZU9

RefSeq (mRNA)


NM_138690


NM_130455

RefSeq (protein)


NP_619635 NP_619635.1


NP_569722

Location (UCSC)

Chr 19: 1 – 1.01 Mb

Chr 10: 79.81 – 79.81 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Glutamate [NMDA] receptor subunit 3B is aprotein that in humans is encoded by theGRIN3Bgene.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000116032 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000035745 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B".

Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death".Neurotoxicology.19 (4–5):683–8.PMID 9745929.
Kornau HC, Schenker LT,Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95".Science.269 (5231):1737–40.Bibcode:1995Sci...269.1737K.doi:10.1126/science.7569905.PMID 7569905.
Magnuson DS, Knudsen BE, Geiger JD, et al. (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity".Ann. Neurol.37 (3):373–80.doi:10.1002/ana.410370314.PMID 7695237.S2CID 24405132.
Lannuzel A, Lledo PM, Lamghitnia HO, et al. (1996). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons".Eur. J. Neurosci.7 (11):2285–93.doi:10.1111/j.1460-9568.1995.tb00649.x.PMID 8563977.S2CID 27201873.
Corasaniti MT, Melino G, Navarra M, et al. (1996). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase".Neurodegeneration.4 (3):315–21.doi:10.1016/1055-8330(95)90021-7.PMID 8581564.
Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120".AIDS.10 (5):463–8.doi:10.1097/00002030-199605000-00003.PMID 8724036.S2CID 1669986.
Wu P, Price P, Du B, et al. (1996). "Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons".NeuroReport.7 (5):1045–9.doi:10.1097/00001756-199604100-00018.PMID 8804048.S2CID 21018147.
Bennett BA, Rusyniak DE, Hollingsworth CK (1996). "HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures".Brain Res.705 (1–2):168–76.doi:10.1016/0006-8993(95)01166-8.PMID 8821747.S2CID 32822686.
Toggas SM, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine".Brain Res.706 (2):303–7.doi:10.1016/0006-8993(95)01197-8.PMID 8822372.S2CID 44260060.
Dreyer EB, Lipton SA (1996). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid".Eur. J. Neurosci.7 (12):2502–7.doi:10.1111/j.1460-9568.1995.tb01048.x.PMID 8845955.S2CID 7370984.
Bonaldo MF, Lennon G, Soares MB (1997)."Normalization and subtraction: two approaches to facilitate gene discovery".Genome Res.6 (9):791–806.doi:10.1101/gr.6.9.791.PMID 8889548.
Raber J, Toggas SM, Lee S, et al. (1997)."Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase".Virology.226 (2):362–73.doi:10.1006/viro.1996.0664.PMID 8955056.
New DR, Maggirwar SB, Epstein LG, et al. (1998)."HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism".J. Biol. Chem.273 (28):17852–8.doi:10.1074/jbc.273.28.17852.PMID 9651389.
Wang P, Barks JD, Silverstein FS (1999). "Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats".Neuroscience.88 (2):585–97.doi:10.1016/S0306-4522(98)00242-5.PMID 10197777.S2CID 28927942.
Howard SA, Nakayama AY, Brooke SM, Sapolsky RM (1999)."Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures".Exp. Neurol.158 (1):164–70.doi:10.1006/exnr.1999.7080.PMID 10448428.S2CID 7598117.
Xin KQ, Hamajima K, Hattori S, et al. (1999). "Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system".AIDS Res. Hum. Retroviruses.15 (16):1461–7.doi:10.1089/088922299309973.PMID 10555109.
Haughey NJ, Nath A, Mattson MP, et al. (2001). "HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity".J. Neurochem.78 (3):457–67.doi:10.1046/j.1471-4159.2001.00396.x.PMID 11483648.S2CID 25641791.
Bonavia R, Bajetto A, Barbero S, et al. (2001). "HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons".Biochem. Biophys. Res. Commun.288 (2):301–8.Bibcode:2001BBRC..288..301B.doi:10.1006/bbrc.2001.5743.PMID 11606043.
Nishi M, Hinds H, Lu HP, et al. (2002)."Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner".J. Neurosci.21 (23): RC185.doi:10.1523/JNEUROSCI.21-23-j0003.2001.PMC 6763906.PMID 11717388.

External links

[edit]

GRIN3B+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

Ion channel,cell surface receptor:ligand-gated ion channels

Cys-loop receptors

5-HT/serotonin	5-HT₃ A B C D E
GABA	GABA_A α₁ α₂ α₃ α₄ α₅ α₆ β₁ β₂ β₃ γ₁ γ₂ γ₃ δ ε π θ GABA_A-ρ ρ₁ ρ₂ ρ₃
Glycine	α₁ α₂ α₃ α₄ β
Nicotinic acetylcholine	monomers:α1 α2 α3 α4 α5 α6 α7 α9 α10 β1 β2 β3 β4 δ ε pentamers:(α3)₂(β4)₃ (α4)₂(β2)₃ (α7)₅ (α1)₂(β4)₃ - Ganglion type (α1)₂β1δε - Muscle type
Zinc	Zinc-activated