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GPRC5D

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GPRC5D

Identifiers

Aliases

GPRC5D, G protein-coupled receptor, class C, group 5, member D, G protein-coupled receptor class C group 5 member D

External IDs

OMIM:607437;MGI:1935037;HomoloGene:10250;GeneCards:GPRC5D;OMA:GPRC5D - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12p13.1	Start	12,940,575bp^[1]
Band	12p13.1	End	12,952,170bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 G1	Start	135,082,989bp^[2]
Band	6\|6 G1	End	135,095,281bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

upper lobe of left lung

hair follicle

mucosa of transverse colon

rectum

right lung

minor salivary glands

bone marrow cell

mucosa of esophagus

islet of Langerhans

Top expressed in

blastocyst

embryo

hair follicle

skin of abdomen

embryo

skin of back

dermis

skin of external ear

sexually immature organism

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	G protein-coupled receptor activity signal transducer activity protein kinase activator activity
Cellular component	integral component of membrane plasma membrane membrane receptor complex intracellular membrane-bounded organelle extracellular exosome
Biological process	G protein-coupled receptor signaling pathway signal transduction activation of protein kinase activity
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


55507


93746

Ensembl


ENSG00000111291


ENSMUSG00000030205

UniProt


Q9NZD1


Q9JIL6

RefSeq (mRNA)


NM_018654


NM_001205396 NM_053118

RefSeq (protein)


NP_061124


NP_001192325 NP_444348

Location (UCSC)

Chr 12: 12.94 – 12.95 Mb

Chr 6: 135.08 – 135.1 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

G-protein coupled receptor family C group 5 member D is aprotein that in humans is encoded by theGPRC5Dgene.^[5] GPRC5D is a class C orphan G protein-coupled receptor predominantly expressed inmultiple myeloma cells and hard keratinized tissues, with low expression in normal human tissues, rendering it an appealing target for multiple myeloma cells.^[6]^[7]^[8]

Structure

[edit]

Structural analysis of the complex between GPRC5D andtalquetamab, a bispecific antibody for the treatment of multiple myeloma, has revealed that GPRC5D exists as a dimer. GPRC5D forms a symmetric dimer via TM4 and TM4/TM5 interactions. The study further demonstrated that only one talquetamab molecule can bind to the dimeric form of GPRC5D. Talquetamab Fab recognizes ECLs and TM3/5/7 of one GPRC5D protomer via six CDRs.^[9]

GPRC5D complexed with Talquetamab Fab (PDB: 9IMA)

Function

[edit]

The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000111291 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000030205 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^b"Entrez Gene: GPRC5D G protein-coupled receptor, family C, group 5, member D".
^"The RAIG family member, GPRC5D, is associated with hard-keratinized structures".J. Invest. Dermatol.
^Smith EL, Harrington K, Staehr M, Masakayan R, Jones J, Long TJ, et al. (March 2019)."GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells".Science Translational Medicine.11 (485).doi:10.1126/scitranslmed.aau7746.PMC 7508042.PMID 30918115.
^Verkleij CP, Broekmans ME, van Duin M, Frerichs KA, Kuiper R, de Jonge AV, et al. (April 2021)."Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma".Blood Advances.5 (8):2196–2215.doi:10.1182/bloodadvances.2020003805.PMC 8095149.PMID 33890981.
^Jeong J, Park J, Young Mo G, Shin J, Cho Y (August 2024). "Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma".Journal of Molecular Biology.436 (20) 168748.doi:10.1016/j.jmb.2024.168748.PMID 39181182.

Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (April 2001). "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D".Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.1518 (3):237–248.doi:10.1016/s0167-4781(01)00197-x.PMID 11311935.
Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence".FEBS Letters.520 (1–3):97–101.Bibcode:2002FEBSL.520...97T.doi:10.1016/S0014-5793(02)02775-8.PMID 12044878.S2CID 7116392.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)