Retinoic acid-induced protein 3 is aprotein that in humans is encoded by theGPRC5Agene.[5][6] This gene and its encoded mRNA was first identified as a phorbol ester-induced gene, and named Phorbol Ester Induced Gen 1 (PEIG-1);[7] two years later it was rediscovered as a retinoic acid-inducible gene, and named Retinoic Acid-Inducible Gene 1 (RAIG1).[5] Its encoded protein was later named Retinoic acid-induced protein 3.
This gene encodes a member of the type 3G protein-coupled receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction betweenretinoic acid andG protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.[6] Tryptamine and other indole related chemicals produced by gut microflora bind and activate the receptor.[8]
^Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA (1996). "Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells".Cell. Mol. Biol. (Noisy-le-grand).42 (5):797–804.PMID8832110.
^Zhao X (2023). "Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A".Nature Chemical Biology.19 (10):1205–1214.doi:10.1038/s41589-023-01328-z.PMID37248411.
Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA (1996). "Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells".Cell. Mol. Biol. (Noisy-le-grand).42 (5):797–804.PMID8832110.
Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain".Genomics.65 (2):121–8.doi:10.1006/geno.2000.6164.PMID10783259.
Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)".Genomics.67 (1):8–18.doi:10.1006/geno.2000.6226.PMID10945465.
Tao Q, Cheng Y, Clifford J, Lotan R (2004). "Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid".Genomics.83 (2):270–80.doi:10.1016/S0888-7543(03)00237-4.PMID14706456.
Hirano M, Zang L, Oka T, Ito Y, Shimada Y, Nishimura Y, Tanaka T (2006). "Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression".Biochem. Biophys. Res. Commun.351 (1):185–91.doi:10.1016/j.bbrc.2006.10.016.PMID17055459.
Mori C, Valdivieso AG, Clauzure M, Massip-Copiz MM, Aguilar MA, Cafferata EG, Santa Coloma TA (2020). "Identification and characterization of human PEIG-1/GPRC5A as a 12-O-tetradecanoyl phorbol-13-acetate (TPA) and PKC-induced gene".Arch. Biochem. Biophys.687 108375.doi:10.1016/j.abb.2020.108375.PMID32339486.S2CID216594760.
"GPRC5 Receptors: RAIG1".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2015-02-03. Retrieved2008-12-04.
